GAS2_MOUSE P11862
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UniProt:P11862
Recommended name：Growth arrest-specific protein 2
EC number：
Alternative names：(GAS-2)
Cleaved into：
GeneID：14453
Gene names (primary )：Gas2
Gene names (synonym )：Gas-2
Gene names (ORF )：
Length：314
Mass：34901
Sequence：MMCTALSPKVRSGPGLSDMHQYSQWLASRHEANLLPMKEDLALWLTNLLGKEITAETFMEKLDNGALLCQLAATVQEKFKESMDANKPAKTLPLKKIPCKASAPSGSFFARDNTANFLSWCRDLGVDETCLFESEGLVLHKQPREVCLCLLELGRIAARYGVEPPGLIKLEKEIEQEETLSAPSPSPSPSSKSSGKKSTGNLLDDAVKRISEDPPCKCPTKFCVERLSQGRYRVGEKILFIRMLHNKHVMVRVGGGWETFAGYLLKHDPCRMLQISRVDGKTSPVQSKSPTLKDMNPDNYLVVSATYKAKKEIK
Tissue specificity：Expressed in most tissues. Highest levels in liver, lung and kidney. In the embryo strongly expressed in regions that undergo extensive apoptosis, such as the intervertebral tissues, the cranofacial mesenchyme and the cartilage of the limbs.
Induction：Down-regulated by mitogens.
Developmental stage：At 11.5 dpc and 13.5 dpc strongly expressed in the soft connective tissue of the face and trunk, and in the invertebral tissues. Low levels are found in brain and neural tube. Low levels are found in 13.5 dpc lung, kidney, eye lens and in vertebral cartilage located cranially. In 11.5 dpc hindlimbs weakly expressed by the mesenchymal cells surrounding the perspective cartilage-forming regions. In 12.5 dpc hindlimbs strongly expressed by cells enveloping the chondrogenic primordia of the digits, metatarsals, tibia, and femur, and the soft connective tissue in the interdigital tissues. In 13.5 dpc hindlimbs expression is maintained in the intergigital tissues located proximally and is found in some chondrocytes in the stylopod and in mesenchymal cells surrounding the cartilage in the autopod and zygopod. In 13.5 dpc forelimb strongly expressed in the pre-hypertrophic and hypertrophic regions of the humerus, radius, and ulna. Expression in hypertrophic chondrocytes is maintained at 14.5 dpc and is not detectable at 15.5 dpc. At day 14.5 dpc also expressed by chondrocytes in the cartilage forming the carpals and tarsals and by mesenchymal cells in the process of condensing to form tendons. In 13.5 dpc hindlimbs expressed in some myoblasts in the proximal myogenic region. In older limbs expression is maintained in the myotubules. {ECO:0000269|PubMed:10049561}.
Protein families：GAS2 family