SEZ6_MOUSE Q7TSK2
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UniProt:Q7TSK2
Recommended name：Seizure protein 6
EC number：
Alternative names：(SEZ-6) (Brain-specific receptor-like protein C) (BSRP-C)
Cleaved into：
GeneID：20370
Gene names (primary )：Sez6
Gene names (synonym )：Kiaa4158
Gene names (ORF )：
Length：991
Mass：107433
Sequence：MRPAALLLLPSLLALLAHGLSSEAPITGEGHATGIRETDGELTAAPTPEQSDRGVHFVTTAPTLKLLNHHPLLEEFLQEGLEREEAPQPALPFQPDSPTHFTPSPLPRLTNQDNRPVFTSPTPAVAAAPTQPHSREKPWNLESKPPELSITSSLPPGPSMAVPTLLPEDRPSTTPPSQAWTPTQEGPGDMDRPWVPEVMSKTTGLGVEGTIATSTASGDDEETTTTIITTTVTTVQPPGPCSWNFSGPEGSLDSPTAPSSPSDVGLDCFYYISVYPGYGVEIKVENISLQEGETITVEGLGGPDPLPLANQSFLLRGQVIRSPTHQAALRFQSLPLPAGPGTFHFRYQAYLLSCHFPRRPAYGDVTVTSLHPGGSAHFHCATGYQLKGARFLTCLNATQPFWDSQEPVCIAACGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPESQRLHLHFEKVSLAEDDDRLIIRNGNNVEAPPVYDSYEVEYLPIEGLLSSGRHFFVEFSTDSSGAAAGMALRYEAFQQGHCYEPFVKYGNFSSSAPSYPVGTTVEFSCDPGYTLEQGSIIIECVDLHDPQWNETEPACRAVCSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGSGDVLTFYDGDDLTARVLGQYSGPRGHFKLFTSMADVTIQFQSDPGTSALGYQQGFVIHFFEVPRNDTCPELPEIPNGWKNPSQPELVHGTVVTYQCYPGYQVVGSSILMCQWDLSWSEDLPSCQRVTSCHDPGDVEHSRRLISSPKFPVGATVQYVCDQGFVLTGSAILTCHDRQAGSPKWSDRAPKCLLEQFKPCHGLSAPENGARSPEKRLHPAGATIHFSCAPGYVLKGQASIKCVPGHPSHWSDPPPICRAASLDGFYNGRSLDVAKAPAASSALDAAHLAAAIFLPLVAMVLLVGGVYLYFSRFQGKSPLQLPRTHPRPYNRITVESAFDNPTYETGSLSFAGDERI
Tissue specificity：Brain-specific. Expressed in extrasynaptic and synaptic subcellular fractions (at protein level). Expression correlates with the most active periods of cortical neurogenesis and neuronal maturation. Expression is restricted to the gray matter with higher levels in the forebrain including the olfactory bulb, anterior olfactory nuclei, olfactory tubercle, striatum, hippocampal CA1 pyramidal cell layer and cerebral cortex. Expression is up-regulated with the convulsant drug, pentylenetetrazole. {ECO:0000269|PubMed:16814779, ECO:0000269|PubMed:7488116, ECO:0000269|PubMed:7723619}.
Induction：
Developmental stage：At 11.5 dpc, expression is localized to the preplate and is absent from the ventricular zone which is the most prominent layer during early cortical development. At 13 dpc highly expressed in postmitotic, maturing neurons of the developing cortical plate and subplate. At 15 dpc expression is closely tied with the emergence of the neocortical layers and hippocampus. In the cortex, expression diminishes after birth, but continues in the deep layer pyramidal neurons and neuronal subpopulations of layer II/III. In the hippocampus, expression persists in CA1 pyramidal neurons and in the dentate gyrus. Postnatally, expression remains high in specific cortical neuron populations, particularly those of the deep cortical layers. {ECO:0000269|PubMed:12351182, ECO:0000269|PubMed:18031681}.
Protein families：SEZ6 family