MACD2_MOUSE Q3UYG8
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UniProt:Q3UYG8
Recommended name：ADP-ribose glycohydrolase MACROD2
EC number：EC 3.5.1.-
Alternative names：(MACRO domain-containing protein 2) (O-acetyl-ADP-ribose deacetylase MACROD2) ([Protein ADP-ribosylaspartate] hydrolase MACROD2) ([Protein ADP-ribosylglutamate] hydrolase MACROD2) (EC 3.2.2.-)
Cleaved into：
GeneID：72899
Gene names (primary )：Macrod2
Gene names (synonym )：
Gene names (ORF )：
Length：475
Mass：52145
Sequence：MYPSNKKKKVWREEKERLLKMTLEERRKEYIRDYVSLSTILSWKEEMKSKGQNDEENTQEAPQMKKSLSEKVSLYRGDITLLEVDAIVNAANASLLGGGGVDGCIHRAAGPCLLAECRNLNGCETGHAKITCGYDLPAKYVIHTVGPIARGHINGSHKEDLANCYQSSLKLVKENNLRSVAFPCISTGIYGFPNEPAAVIALGTIKEWLAKNHQEVDRIIFCVFLEVDFKIYKKKMNEFFPVDDNNEGTDADMKEDSEGPEPKGLSPPHKKSKAKKPESSKDSSEDESGPEEKQTAEEMEGQSQEAGGLRFLLRNLLGLIHRDGVNTTPVPSPASEDKAEVHKDEDSAKDDNTVKDSDMTNHSVCDQELPNGQENDSAKSEGKTEAESPSSSMETEDLSPNQEDAAIVEQPEVIPLIDDQEAQEGGEAQGKDAPAVFAESQGSSEAENTSGPDVDMNSQVDGVNEPTESLQEDLQ
Tissue specificity：Expressed in the kidney. {ECO:0000269|PubMed:17586838}.
Induction：
Developmental stage：At 12.5 dpc, expressed in the neural tube and in the dorsal root and cranial ganglia. At 14.5 dpc, expressed in metanephric glomeruli, but not in the medullary region of the kidney, in the epithelium lining the gut, the stomach and the seminiferous tubules, as well as in lung. Expression is maintained in the dorsal root and cranial ganglia. In the cranial region, up-regulated in the epithelial and mesenchymal components of the tooth bud, in the epithelium lining the primitive nasal cavity, the vestibulocochlear and cochlear ducts and in the cranial ganglia. At 16.5 dpc, expression is maintained in kidney and lung. Detected in the papilla of the whisker follicle. In the eye, highly expressed in the cuboid epithelium of the lens and the inner nuclear (neuroblastic) layer of the retina. Expression begins in the brain, in particular the ventricular zone, and in the heart. At 18.5 dpc, expression is maintained in the brain, including the subventricular zone of striatum and olfactory lobe, the cortical plate, the cerebellar primordium and the inferior colliculus of the tectum. At this stage, the expression in the heart is 45 times lower than in the brain. At birth, still detectable in the metanephric glomeruli, but not in the adrenal gland. {ECO:0000269|PubMed:17586838}.
Protein families：