ELAV4_MOUSE Q61701
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UniProt:Q61701
Recommended name：ELAV-like protein 4
EC number：
Alternative names：(Hu-antigen D) (HuD) (Paraneoplastic encephalomyelitis antigen HuD)
Cleaved into：
GeneID：15572
Gene names (primary )：Elavl4
Gene names (synonym )：Hud
Gene names (ORF )：
Length：385
Mass：42368
Sequence：MEWNGLKMIISTMEPQVSNGPTSNTSNGPSSNNRNCPSPMQTGAATDDSKTNLIVNYLPQNMTQEEFRSLFGSIGEIESCKLVRDKITGQSLGYGFVNYIDPKDAEKAINTLNGLRLQTKTIKVSYARPSSASIRDANLYVSGLPKTMTQKELEQLFSQYGRIITSRILVDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPSGATEPITVKFANNPSQKSSQALLSQLYQSPNRRYPGPLHHQAQRFRLDNLLNMAYGVKRLMSGPVPPSACPPRFSPITIDGMTSLVGMNIPGHTGTGWCIFVYNLSPDSDESVLWQLFGPFGAVNNVKVIRDFNTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGDRVLQVSFKTNKAHKS
Tissue specificity：Expressed in the brain, including the hippocampus, and in pancreatic beta cells (at protein level) (PubMed:22387028, PubMed:18493953, PubMed:15764704, PubMed:24599466). Expressed in pyramidal neurons of the hippocampal CA3 and CA1 region and in the hilus but not in dentate granule cells (at protein level) (PubMed:15519747). Expressed in the dorsal root ganglion and the spinal cord (at protein level) (PubMed:17035636, PubMed:28111162). Expressed in neural stem and progenitor cells (at protein level) (PubMed:16554442). Expressed in radial glia-like cells and in transient amplifying cells in the subventricular zone (SVZ), and in immature neurons both in the SVZ and the rostral migratory stream as well as in mature neurons in the olfactory bulb (at protein level) (PubMed:26305964). Expressed in testis and in the brain, including the hippocampus, the neocortex and the cerebellum (PubMed:8535975, PubMed:11573004, PubMed:24857657). Expressed in lower- but not upper-layer primary neurons of the mature neocortex, in the hippocampal regions CA1-3 and the dentate gyrus (PubMed:24599466, PubMed:9096138). Expressed in the mitral and granule cells of the olfactory bulb, cerebral cortex, entorhinal cortex, thalamus, medial habenula, amygdala, granule cells of the cerebellum, pons, olivary nucleus, dorsal and ventral spinal cord and in dorsal root ganglia (PubMed:9096138). Expressed in motor neurons (PubMed:21389246). Isoform 4: Expressed in the brain (PubMed:9096138, PubMed:22895702). Isoform 5: Expressed in the brain (PubMed:9096138). Isoform 6: Expressed in the brain (PubMed:22895702). Isoform 7: Expressed in the brain (PubMed:22895702). Isoform 8: Expressed in the brain (PubMed:22895702). Isoform 9: Expressed in the brain (PubMed:22895702). Isoform 10: Expressed in the brain (PubMed:22895702). Isoform 11: Expressed in the brain (PubMed:22895702). {ECO:0000269|PubMed:11573004, ECO:0000269|PubMed:15519747, ECO:0000269|PubMed:15764704, ECO:0000269|PubMed:16554442, ECO:0000269|PubMed:17035636, ECO:0000269|PubMed:18493953, ECO:0000269|PubMed:21389246, ECO:0000269|PubMed:22387028, ECO:0000269|PubMed:22895702, ECO:0000269|PubMed:24599466, ECO:0000269|PubMed:24857657, ECO:0000269|PubMed:26305964, ECO:0000269|PubMed:28111162, ECO:0000269|PubMed:8535975, ECO:0000269|PubMed:9096138}.
Induction：Up-regulated by glucose and by insulin (PubMed:22387028). Up-regulated after memory training in radial arm maze experiments (PubMed:11573004). Up-regulated after sciatic nerve injury (PubMed:28111162). Up-regulated during adult neuronal stem cell differentiation (PubMed:26305964). {ECO:0000269|PubMed:11573004, ECO:0000269|PubMed:22387028, ECO:0000269|PubMed:26305964, ECO:0000269|PubMed:28111162}.
Developmental stage：At 14 dpc, expressed in the intermediate zone of the cortex (PubMed:9096138). At 15 dpc, high expression in the neocortex, with decreased expression at postnatal day 7 and in adulthood (PubMed:24599466). At 16 dpc and at birth, expressed in the retina, thalamus, hypothalamus, midbrain, pons, dorsal and ventral spinal cord, and the dorsal root ganglia (PubMed:9096138). At birth, expressed in the nasal epithelium, olfactory bulb, trigeminal ganglia, cerebral cortex, the pyramidal cells of the hippocampus and the sympathetic ganglia (PubMed:9096138). Widely expressed in the cerebellum at postnatal day 9 (PubMed:9096138). Isoform 4: Highly expressed in the brain at 10 dpc to 14 dpc, with decreased expression at 16 dpc and at postnatal day 8 (PubMed:9096138). Isoform 5: Highly expressed in the brain at 10 dpc, with decreased expression at 16 dpc and at postnatal day 8 (PubMed:9096138). Isoform 6: Expressed in the brain at 14 dpc (PubMed:22895702). Isoform 7: Expressed in the brain at 14 dpc (PubMed:9096138). Isoform 8: Expressed in the brain at 14 dpc (PubMed:9096138). Isoform 9: Expressed in the brain at 14 dpc (PubMed:9096138). Isoform 10: Expressed in the brain at 14 dpc, including the amygdala, hippocampus and cerebral cortex, and strong expression in the olfactory bulb and retina (PubMed:22895702). Isoform 11: Expressed in the brain at 14 dpc (PubMed:9096138). {ECO:0000269|PubMed:22895702, ECO:0000269|PubMed:24599466, ECO:0000269|PubMed:9096138}.
Protein families：RRM elav family