DUSTY_MOUSE Q6XUX1
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UniProt:Q6XUX1
Recommended name：Dual serine/threonine and tyrosine protein kinase
EC number：EC 2.7.12.1
Alternative names：(Dusty protein kinase) (Dusty PK) (Receptor-interacting serine/threonine-protein kinase 5)
Cleaved into：
GeneID：213452
Gene names (primary )：Dstyk
Gene names (synonym )：Ripk5
Gene names (ORF )：
Length：927
Mass：104901
Sequence：MEADGQSWAGESVSGPGPGGGGMIRELCRGFSRYRRYLGRLRQNLRETQKFFRDIKCSHSHSCPSSPAGGGAAELGPAGDVAEAPLPAGQLSCISFPPMEETYLQQLVDRLPCILILGQDCNAKCQLLNLLLGVQVLPTLKLDSDESCKLRRLRFTYGTRTRVSLALPGQYELVHTLASHQDNWETIPEEDLEVQEDSEDAAHVLADLEVTMHHALLQEVDIVVAPCPSHRPSVDVLSDLANDFLPVITYALHKDELSERGEQELREVRQYFSFPMFFFKVPKLEIISSSSGRAESERSPLYGQLVDLGYLSSSHRNCVPSDQDCKAQSMLVEQSEKLKQLSTFSHQLLQNRLVDAAKALNVVHSHCLDIFINQAFDMQRDLQITPKRLEYTRKKENELYESLMNIANRKQEEMKDMIVETLNTMKEELLDDAANMEFKDVIVPENGETIGTREIKSCIRQIQELIISRLNQAVANKLISSVDYLRESFVGTLERCLQSLEKSQDVSVHITSNYLKQILNAAYHVEVTFHSGSSVTRMLWEQIKQIIQRITWVNPPTITLEWKRKVAQEAIDSLSASKLAKSICSQFRTRLNSSHEAFAASLRQLEAGHSGRLEKTEDLWLKVRKDHAPRLARLSLESRSLQDVLLHRKPKLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYNYGGGSSVAVLLIMERLHRDLYTGLKAGLTLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGKYDNSVDVYAFGILFWYICSGSIKLPEAFERCASKDHLWNNVRRGTRPERLPVFDEECWQLMEACWDGDPLKRPLLGIVQPMLRSIMDRLCKCSSEQPNRGLDDST
Tissue specificity：Expressed in brain, heart, skeletal muscle, kidney and lung. Expressed in maturing tubular epithelia, with the most prominent expression in the medulla and the papilla. Expressed in thin ascending limb of the loop of Henle and the distal convoluted tubule. Expressed in all layers of transitional ureteric epithelium and in the ureteric smooth-muscle cells (at protein level). Widely expressed. Highly expressed in many brain regions, including in cerebellum, olfactory, hippocampus and cerebral cortex. {ECO:0000269|PubMed:17123648, ECO:0000269|PubMed:23862974}.
Induction：
Developmental stage：At 14.5 dpc detected in lung and skeletal muscle, and by 18.5 dpc detected in skin, whisker, gut and testis. {ECO:0000269|PubMed:17123648}.
Protein families：Protein kinase superfamily, Ser/Thr protein kinase family