MK08_MOUSE Q91Y86
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UniProt:Q91Y86
Recommended name：Mitogen-activated protein kinase 8
EC number：EC 2.7.11.24
Alternative names：(MAP kinase 8) (MAPK 8) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1)
Cleaved into：
GeneID：26419
Gene names (primary )：Mapk8
Gene names (synonym )：Jnk1 Prkm8
Gene names (ORF )：
Length：384
Mass：44229
Sequence：MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEERTKNGVIRGQPSPLAQVQQ
Tissue specificity：Brain (at protein level). {ECO:0000269|PubMed:22441692}.
Induction：In T-cells, following T-cell receptor (TCR) activation. Levels peak 48 hours after TCR and CD-28 costimulation. {ECO:0000269|PubMed:10811224}.
Developmental stage：At 15.5 dpc, mid to low expression throughout the midbrain, with more prominent levels in the telencephalon, especially in the intermediate zone, the midbrain roof, the olfactory epithelium, the inferior colliculus, and the medulla oblongata. telencephalon revealed concentrated (at protein level). {ECO:0000269|PubMed:16618812}.
Protein families：Protein kinase superfamily, CMGC Ser/Thr protein kinase family, MAP kinase subfamily