NUAK1_MOUSE Q641K5
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UniProt:Q641K5
Recommended name：NUAK family SNF1-like kinase 1
EC number：EC 2.7.11.1
Alternative names：(AMPK-related protein kinase 5) (Omphalocele kinase 1)
Cleaved into：
GeneID：77976
Gene names (primary )：Nuak1
Gene names (synonym )：Kiaa0537 Omphk1
Gene names (ORF )：
Length：658
Mass：73661
Sequence：MEGAAVSAAGDGPAVETGLPGSPLEAVAGATAAPVEPRKPHGVKRHHHKHNLKHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDELDMVHIRREIEIMSSLNHPHIISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWALGVLLYTLIYGTMPFDGFDHKNLIRQISSGEYREPTQPSDARGLIRWMLMVNPDRRATIEDIANHWWVNWGYKSSVCDCDALPDSESPLLARIIDWHHRSTGLQAEAEAKMKGLAKPGASEVVLERQRSLKKSKKENDFPQSGQDSVPESPSKLSSKRPKGILKKRSNSEHRSHSTGFIEGIVSPALPSPFKMEQDLCRTAIPLPSSPEADMSGKLSLKQSATMPKKGILKKTQQRESGYYSSPERSESSELLDSNDVVISGGLSSPPPDPARGTSHSLSCRRKGILKHSSRYSDGGTDPALTRPEMPTLESLSPPGVPSDGISRSYSRPSSIISDDSVLSSDSFDLLELQENRPARQRIRSCVSAENFLQLQDFETPHNRPRPQYLKRLADSSFSLLTDMDDVTQVYKKALEICSKLN
Tissue specificity：Expressed in the developing central nervous system, in epidermis, and some other tissues. {ECO:0000269|PubMed:16715502}.
Induction：
Developmental stage：At 7.5 dpc, expressed in allantois and anterior visceral endoderm. In the embryonic part, present in mesoderm migrating laterally but not in the primitive streak; the expression is not apparent in ectoderm or endoderm at this stage. At 8.5 dpc, no expression is found in mesodermal tissues, while it is expressed in midbrain and isthmic regions of the neuroectoderm; it is also found in the pharyngeal region of the foregut. At 9.5 dpc, the expression is found throughout the undifferentiated neuroectoderm, except the telencephalic region. The expression is also ubiquitous in the epidermis; it is especially apparent in the ventral body wall. Also expressed in dorsal root ganglia of neural crest origin. The expression persists in the anterior gut and is also found in bulb arteriosus, kidney, and several connective tissues. At 12.5 dpc, the expression is greatly reduced in most of the neuroectoderm, but some expression remains in pons, anterior tectum, tegmentum, pretectum, prethalamus, mammillary region and hypothalamus. In telencephalon, expression is present in the differentiating preplate of the cortex. The expression is sustained in the epidermis of the whole body. In 14.5 and 18.5 dpc brain, expressed in differentiated fields of the cortex; no significant expression is found in other parts of brain or in the spinal cord. The expression is also present in a variety of connective tissues and in the epidermis of the whole body. {ECO:0000269|PubMed:16715502}.
Protein families：Protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily