CXA1_MOUSE P23242
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UniProt:P23242
Recommended name：Gap junction alpha-1 protein
EC number：
Alternative names：(Connexin-43) (Cx43) (Gap junction 43 kDa heart protein)
Cleaved into：
GeneID：14609
Gene names (primary )：Gja1
Gene names (synonym )：Cxn-43
Gene names (ORF )：
Length：382
Mass：43004
Sequence：MGDWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCENVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDGVNVEMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSVFEVAFLLIQWYIYGFSLSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFKGVKDRVKGRSDPYHATTGPLSPSKDCGSPKYAYFNGCSSPTAPLSPMSPPGYKLVTGDRNNSSCRNYNKQASEQNWANYSAEQNRMGQAGSTISNSHAQPFDFPDDSQNAKKVAAGHELQPLAIVDQRPSSRASSRASSRPRPDDLEI
Tissue specificity：Expressed in heart, non-sensory epithelial cells, and in fibrocytes of the spiral ligament and the spiral limbus. Expressed in bladder smooth muscle cells (at protein level). Expressed in astrocytes (at protein level) (PubMed:15213231). {ECO:0000269|PubMed:11741837, ECO:0000269|PubMed:15213231, ECO:0000269|PubMed:2178193, ECO:0000269|PubMed:22549838}.
Induction：In bladder smooth muscle cells, exhibits night/day variations with low levels during the sleep phase, at circadian time (CT) 4-12 (at protein level). Down-regulation during the night allows increase in bladder capacity, avoiding disturbance of sleep by micturition. Expression starts to increase around CT12 and forms a plateau during the active phase (CT16-24) (at protein level). Circadian transcription is activated by NR1D1. Up-regulated by SP1 and SP3. {ECO:0000269|PubMed:22549838}.
Developmental stage：At 7.5 dpc, expressed in the embryo, but not in the extraembryonic region containing the ectoplacental cone. {ECO:0000269|PubMed:8395450}.
Protein families：Connexin family, Alpha-type (group II) subfamily