PALD_MOUSE P70261
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UniProt:P70261
Recommended name：Paladin
EC number：
Alternative names：
Cleaved into：
GeneID：27355
Gene names (primary )：Pald1
Gene names (synonym )：Pald
Gene names (ORF )：
Length：859
Mass：96740
Sequence：MGTTASTAQQTVSAGTSLEGLQGGSSSSMDSQHSLGGVQSFRATSLHNSKAKSIIPNKVAPVVITYNCKEEFQIHDELLKAHYRMGRLSDATPEHYLVQGRYFLVRDITEKMDILGTLKSCGAPNFRQVRGGLPVFGMGQPSLLGFRRVLQKLQTDGLKECIIFCVREEPVVFLRAEEDFVSYTPRDKESLHENLRDPSPGVKAENLELAIQKEIHDFAQLRDNVYHVYHNTEDLRGEPHTVAIRGEDGVCVTEEVFKRPLLLQPTYRYHHLPLPEQGPPLEAQFDAFVSVLRETPSLLPLRDNHGPLPALLFSCQSGVGRTNLGMVLGTLVMFHHSRTTSQLEAASPLAKPLPMEQFQVIQGFICKVPQGKKMVEEVDRAISACAELHDLKEEVLKNQRRLESFRPESRGQECGSQQAVQQRALWSLELYFYLLLFNYYLHEQYPLAFALSFSRWLCTHPELYRLLVELNSVGPLVPGDLIAKGSLEADDLVSLDALSTVREMDVANFRRVPRMPIYGTAQPSAKALGNILAYLSDAKRKLRQVVWIFLREEVVLECDGHTHSLWPPGPALAPEHLVALEAQLKAHLSAPVPNTKSPTAPRFQKCLTTQEVFSQHQGACLGLTYCRIPVPDFCAPREEDFDRLLEALRAALTKDPGTGFVFSCLSGQGRTTTAMVVAVLACWHIGGCPEVGEEELVSVPDAKFTKGEFQVVMKVVQLLPDGHHVKKEVDAALDIVSETMTPMHYHLREIIISTYRQAKATKEAQEAQRLQLRSLQYLERYIYLILFNAYLRLEKTSSWQRPFSTWMREVATKAGIYEILNQLGFPELESIEEQPLSRLRYRWQEQSRDPEPCDVGDFL
Tissue specificity：Vascular expression detected in the central nervous system, kidney, lung, heart, skeletal muscle, white adipose tissue (WAT), brown adipose tissue, liver, pancreas and spleen. Not expressed in all vessels: for instance, not expressed in capillaries in the brain, and expressed mainly in large vessels in the heart, WAT, liver, pancreas and kidney. Predominant nonvascular expression in myocardium and lung mesenchyme. In large vessels, primarily expressed by smooth muscle cells, but occasionally detected at low levels in the endothelium. Expressed in various cells of the hematopoietic lineage. {ECO:0000269|PubMed:22354871}.
Induction：
Developmental stage：At 9.5 and 10.5 dpc, weak but general expression in the intersomitic mesenchyme. Higher levels of expression in the intersomitic vessels and other developing small and large blood vessels. Expressed in the notochord and the roof and floor plates of the neural tube. Expressed along rhombomeres 2 and 4, as well as pharyngeal arches 1 and 2, possibly in neural crest cells. No expression in the somites. At 14.5 dpc, predominantly expressed in all vessels, capillaries (at protein level), arteries and veins. Strong vascular expression observed in neural tissue, skeletal muscle, skin, kidney, liver, and along the gastrointestinal tract. Nonvascular expression detected in heart myocardium, lung and kidney mesenchyme (at protein level). During postnatal vascular development, expression shifts from capillary and venous vessels to arteries, from endothelial cells to vascular smooth muscle cells. {ECO:0000269|PubMed:22354871}.
Protein families：Paladin family