TBA8_MOUSE Q9JJZ2
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UniProt:Q9JJZ2
Recommended name:Tubulin alpha-8 chain
EC number:
Alternative names:(Alpha-tubulin 8)
Cleaved into:
GeneID:53857
Gene names (primary ):Tuba8
Gene names (synonym ):
Gene names (ORF ):
Length:449
Mass:50052
Sequence:MRECISVHVGQAGVQIGNACWELFCLEHGIQADGTFGTQASKINDDDSFTTFFSETGNGKHVPRAVMVDLEPTVVDEVRAGTYRQLFHPEQLITGKEDAANNYARGHYTVGKESIDLVLDRIRKLTDACSGLQGFLIFHSFGGGTGSGFTSLLMERLSLDYGKKSKLEFAIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLVTYAPIISAEKAYHEQLSVAEITSSCFEPNSQMVKCDPRHGKYMACCMLYRGDVVPKDVNVAIAAIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGTDSFEEENEGEEF
Tissue specificity:Expressed at highest levels in the testis, followed by skeletal and heart muscle. Expressed at low levels in the developing brain. {ECO:0000269|PubMed:20466094}.
Induction:
Developmental stage:At embryonic day (E) 13.5, expressed in the cortical preplate and cingulate cortex. By 15.5 dpc, the strongest expression is seen in the cortical plate. By 18.5 dpc, cortical expression is most intense in the upper layers and subplate. There is strong expression in the areas CA1-3 of the hippocampus. At P0, cortical expression is strongest in the dense cortical plate and subplate. Hippocampal expression is more intense in areas CA1-3 than in the dentate gyrus. At P8, lamination is almost complete and cortical expression is strongest in layers II-III and V and the subplate. There is also expression in the mediodorsal nuclei of the thalamus, the mitral cell layer of the olfactory bulb, and the external granular layer, molecular layer, and internal granular cell layer of the cerebellum. {ECO:0000269|PubMed:19896110, ECO:0000269|PubMed:20466094}.
Protein families:Tubulin family