KIRR3_MOUSE Q8BR86
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UniProt:Q8BR86
Recommended name：Kin of IRRE-like protein 3
EC number：
Alternative names：(Kin of irregular chiasm-like protein 3) (Nephrin-like protein 2) (mKirre)
Cleaved into：Processed kin of IRRE-like protein 3
GeneID：67703
Gene names (primary )：Kirrel3
Gene names (synonym )：Kiaa1867 Neph2
Gene names (ORF )：
Length：778
Mass：85405
Sequence：MRPFQLDLLFLCFFLFSQELGLQKRGCCLVLGYMAKDKFRRMNEGQVYSFSQQPQDQVVVSGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPIILGGPVISLRAGDPLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNIVTFHCSAKANPAVTQYRWAKRGHIIKEASGELYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTSEPQSLLVDLGSDAVFSCAWIGNPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETVNTEEGVISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGVAVGAGVAFLVLMATIVAFCCARSQRNLKGVVSAKNDIRVEIVHKEPSSGREAEDHTTIKQLMMDRGEFQQDSVLKQLEVLKEEEKEFQNLKDPTNGYYSVNTFKEHHSTPTISLSSCQPDLRPTGKQRVPTGMSFTNIYSTLSGQGRLYDYGQRFVLGMGSSSIELCEREFQRGSLSDSSSFLDTQCDSSVSSSGKQDGYVQFDKASKASASSSHHSQSSSQNSDPSRPLQRRMQTHV
Tissue specificity：Expressed mainly in adult brain, bone marrow and stromal cells (PubMed:12665856). Expressed in diverse regions of the brain, including the cortex, hippocampus, striatum, olfactory bulb and cerebellum (PubMed:15908127, PubMed:26283919). In brain, expressed in pontine nucleus neurons (at protein level) (PubMed:21241806). In hippocampus, produced in both the dentate granule neurons and the GABAergic neurons, but not the CA3 neurons (PubMed:26575286). Expressed in subpopulations of vomeronasal sensory neurons (PubMed:23637329). Expressed in a subset of neurons in dorsal root ganglia (PubMed:18752272). {ECO:0000269|PubMed:12665856, ECO:0000269|PubMed:15908127, ECO:0000269|PubMed:18752272, ECO:0000269|PubMed:21241806, ECO:0000269|PubMed:23637329, ECO:0000269|PubMed:26283919, ECO:0000269|PubMed:26575286}.
Induction：
Developmental stage：At embryonic day 11.5, it is expressed in the differentiating zones of various regions, such as the caudate-putamen, the geniculate body, the thalamus, the amygdala and the brainstem. This expression persists in the adult, although expression is lower. After birth, highly expressed in the glomerular and mitral layers of the olfactory bulb, the cortical plate of the neocortex, the cochlear nucleus, and the molecular and granule cell layers of the cerebellum. In the hippocampus, expression is first observed in the dentate gyrus at postnatal day 7. {ECO:0000269|PubMed:15908127}.
Protein families：Immunoglobulin superfamily