TECRL_MOUSE   Q8BFZ1


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UniProt:Q8BFZ1

Recommended name:Trans-2,3-enoyl-CoA reductase-like

EC number:EC 1.3.1.-

Alternative names:(Steroid 5-alpha-reductase 2-like 2 protein)

Cleaved into:

GeneID:243078

Gene names  (primary ):Tecrl

Gene names  (synonym ):Srd5a2l2

Gene names  (ORF ):

Length:361

Mass:41893

Sequence:MFKRHKSLERKRELLFQGLPQSTMKNNARNFHSLSQLVLSAGPLKTTTAVKHSKTTHFEIEILDAHTRKQICIVDKVTQTSTIHDVKQKFHKACPKWYPSRIGLQLEYGGPYLRDYITVQSVAASSIITLYFTDLGQQVGWTTVFLAEYSGPLLIYLLFYLRSSYIYDVKESTRWPRHPVVHLAFFCHCIHYIRLLLETLFVHKVSTGHSPMKNLIKGCAFYWGFTSWMAYYINHPRYTPPSFGNRQVIVSAINFLFCEAGNHFINTVLAHPNHTGSNACFPSPNYNPFTWLFFLVSCPNYTYEIGSWISFTVMTQTLPVGIFTILMTIQMSLWARKKHKIYRKKFNSYVHRKSAIIPLIL

Tissue specificity:Expression is highest in the heart with very low to almost undetectable levels in brain, skeletal muscle, stomach, pancreas, liver, kidney, small intestine, and uterus. {ECO:0000269|PubMed:27861123}.

Induction:

Developmental stage:At embryonic day 8.5 dpc, expressed in the developing heart with the strongest expression occurring in the inflow tract, especially in the left horn. At 9.5 dpc, expression is still detectable in the atria and ventricles, albeit at lower levels whereas strong expression remains in the inflow tract. From 10 dpc onwards, it is also expressed at low levels in somites, particularly in the myotome region, that gives rise to skeletal muscle. At 10.5 dpc, cardiac expression is no longer restricted to the inflow tract. At 14.5 dpc, it is expressed in the entire myocardium. {ECO:0000269|PubMed:27861123}.

Protein families:Steroid 5-alpha reductase family


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