MXRA8_MOUSE Q9DBV4
We list detailed information on various proteins on this webpage, which EnkiLife references when developing protein-related products. The protein data is sourced from UniProt, and since UniProt updates its information periodically, the data on our webpage may not always be up-to-date or may contain inaccuracies. If you notice any errors while browsing, we warmly welcome your feedback. Additionally, if you have any suggestions regarding any aspect of our website, please feel free to share them with us. As a token of our appreciation, we will offer a free product or a discount voucher for purchases to scientists who provide feedback. Please contact us at Email: order@enkilife.com; to share your feedback and get your rewards.
UniProt:Q9DBV4
Recommended name：Matrix remodeling-associated protein 8
EC number：
Alternative names：(Adipocyte-specific protein 3) (Dual Ig domain-containing cell adhesion molecule) (DICAM) (Limitrin)
Cleaved into：
GeneID：74761
Gene names (primary )：Mxra8
Gene names (synonym )：Asp3 Dicam
Gene names (ORF )：
Length：442
Mass：49750
Sequence：MELLSRVLLWKLLLLQSSAVLSSGPSGTAAASSSLVSESVVSLAAGTQAVLRCQSPRMVWTQDRLHDRQRVVHWDLSGGPGSQRRRLVDMYSAGEQRVYEPRDRDRLLLSPSAFHDGNFSLLIRAVDRGDEGVYTCNLHHHYCHLDESLAVRLEVTEDPLLSRAYWDGEKEVLVVAHGAPALMTCINRAHVWTDRHLEEAQQVVHWDRQLPGVSHDRADRLLDLYASGERRAYGPPFLRDRVSVNTNAFARGDFSLRIDELERADEGIYSCHLHHHYCGLHERRVFHLQVTEPAFEPPARASPGNGSGHSSAPSPDPTLTRGHSIINVIVPEDHTHFFQQLGYVLATLLLFILLLITVVLATRYRHSGGCKTSDKKAGKSKGKDVNMVEFAVATRDQAPYRTEDIQLDYKNNILKERAELAHSPLPAKDVDLDKEFRKEYCK
Tissue specificity：Widely expressed (at protein level) (PubMed:18366072). Highly expressed in brain where it localizes to the glia limitans, which is formed by the endfeet of astrocytes surrounding capillaries, and beneath the pia mater (at protein level) (PubMed:14603461). In lung, detected in epithelial cells of the bronchus (at protein level). Expressed in intercalated disks in the heart (at protein level) (PubMed:18366072). Detected in pancreatic alpha-cells in the islet of Langerhans (at protein level) (PubMed:18366072). In kidney, found in the brush border of the proximal convoluted tubule (at protein level) (PubMed:18366072). Expressed in the epithelium of the small intestine (at protein level) (PubMed:18366072). Weakly expressed in liver (at protein level) (PubMed:18366072). Detected in myeloid cells (PubMed:22492581). {ECO:0000269|PubMed:14603461, ECO:0000269|PubMed:18366072, ECO:0000269|PubMed:22492581}.
Induction：Disruption of the blood-brain barrier by cold injury results in a drastic reduction in expression (PubMed:14603461). Up-regulated in primary chondrocytes in response to BMP2 and PTHLH/PTHrP (PubMed:29702220). {ECO:0000269|PubMed:14603461, ECO:0000269|PubMed:29702220}.
Developmental stage：At embryonic stage 15.5 dpc, expressed in the growth plate of long bones where it is mostly found in chondrocytes in the resting and proliferative zones (at protein level) (PubMed:29702220). Expression gradually increases in differentiating osteoclasts, but then decreases during the late stages of differentiation (PubMed:22492581). {ECO:0000269|PubMed:22492581, ECO:0000269|PubMed:29702220}.
Protein families：