GDF15_MOUSE Q9Z0J7
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UniProt:Q9Z0J7
Recommended name：Growth/differentiation factor 15
EC number：
Alternative names：(GDF-15) (Macrophage inhibitory cytokine 1) (MIC-1)
Cleaved into：
GeneID：23886
Gene names (primary )：Gdf15
Gene names (synonym )：Mic1 Sbf
Gene names (ORF )：
Length：303
Mass：33225
Sequence：MAPPALQAQPPGGSQLRFLLFLLLLLLLLSWPSQGDALAMPEQRPSGPESQLNADELRGRFQDLLSRLHANQSREDSNSEPSPDPAVRILSPEVRLGSHGQLLLRVNRASLSQGLPEAYRVHRALLLLTPTARPWDITRPLKRALSLRGPRAPALRLRLTPPPDLAMLPSGGTQLELRLRVAAGRGRRSAHAHPRDSCPLGPGRCCHLETVQATLEDLGWSDWVLSPRQLQLSMCVGECPHLYRSANTHAQIKARLHGLQPDKVPAPCCVPSSYTPVVLMHRTDSGVSLQTYDDLVARGCHCA
Tissue specificity：Highly expressed in liver (PubMed:10779363, PubMed:28572090, PubMed:29046435). Detected in plasma (at protein level) (PubMed:28572090, PubMed:29046435). Expressed by cardiomyocytes, expression is highly increased in heart diseases (PubMed:28572090). Also detected in subcutaneous fat (PubMed:28572090, PubMed:29046435). {ECO:0000269|PubMed:10779363, ECO:0000269|PubMed:28572090, ECO:0000269|PubMed:29046435}.
Induction：Expression is up-regulated by obesity. {ECO:0000269|PubMed:29046435}.
Developmental stage：At postnatal day 3 (P3), detected in heart and plasma, expression decreases with lower levels at P7 to, at least, P13. {ECO:0000269|PubMed:28572090}.
Protein families：TGF-beta family