PRRT2_MOUSE E9PUL5
We list detailed information on various proteins on this webpage, which EnkiLife references when developing protein-related products. The protein data is sourced from UniProt, and since UniProt updates its information periodically, the data on our webpage may not always be up-to-date or may contain inaccuracies. If you notice any errors while browsing, we warmly welcome your feedback. Additionally, if you have any suggestions regarding any aspect of our website, please feel free to share them with us. As a token of our appreciation, we will offer a free product or a discount voucher for purchases to scientists who provide feedback. Please contact us at Email: order@enkilife.com; to share your feedback and get your rewards.
UniProt:E9PUL5
Recommended name：Proline-rich transmembrane protein 2
EC number：
Alternative names：(Dispanin subfamily B member 3) (DSPB3)
Cleaved into：
GeneID：69017
Gene names (primary )：Prrt2
Gene names (synonym )：
Gene names (ORF )：
Length：346
Mass：35924
Sequence：MAASSSQVSEMKGVEDSSKTQTEGPRHSEEGLGPVQVVAEIPDQPEALQPGPGITAAPVDSGPKAELAPETTETPVETPETVQATDLSLNPEEGSKASPSPSPSEARQEPASKPDVNRETAAEEGSEPQSTAPPEPTSEPAFQINTQSDPQPTSQPPPKPPLQAEPPTQEDPTTEVLTESTGEKQENGAVVPLQAGDGEEGPAPQPHSPPSTKTPPANGAPPRVLQKLVEEDRIGRAHGGHPGSPRGSLSRHPSSQLAGPGVEGGEGTQKPRDYIILAILSCFCPMWPVNIVAFAYAVMSRNSLQQGDVDGAQRLGRVAKLLSIVALVGGVLIIIASCVINLGVYK
Tissue specificity：Neuron-specific expression throughout the brain, with the highest levels in the cerebellum, basal ganglia, hippocampus, substantia nigra, and neocortex (at protein level) (PubMed:22101681, PubMed:22243967, PubMed:22832103, PubMed:22632720, PubMed:25915028, PubMed:27052163, PubMed:27172900, PubMed:28007585, PubMed:29056747). Highly expressed also in spinal cord (at protein level) (PubMed:22101681, PubMed:22832103). Detected at very low levels in the heart, lung, kidney and skin (PubMed:22101681). {ECO:0000269|PubMed:22101681, ECO:0000269|PubMed:22243967, ECO:0000269|PubMed:22632720, ECO:0000269|PubMed:22832103, ECO:0000269|PubMed:25915028, ECO:0000269|PubMed:27052163, ECO:0000269|PubMed:27172900, ECO:0000269|PubMed:28007585, ECO:0000269|PubMed:29056747}.
Induction：
Developmental stage：At the mRNA level, expressed at low levels in the developing brain before 16 dpc. Expression markedly increases during early postnatal stages with a peak at P14. At this stage, expressed throughout the brain, with high levels in the cerebral cortex (cortical layers), hippocampus and cerebellum (granule cells and Purkinje cell layers). Progressively declines to relatively low levels in adulthood. At the protein level, first detected at very low levels at 17.5 dpc. Expression increases at early postnatal stages in the cerebral cortex, hippocampus and cerebellum. Expression increases to reach a plateau around P14, a period of intense synapse formation and rearrangement, and starts to slightly decrease around P90 (at protein level) (PubMed:27052163, PubMed:29056747). {ECO:0000269|PubMed:22101681, ECO:0000269|PubMed:27052163, ECO:0000269|PubMed:29056747}.
Protein families：CD225/Dispanin family