HMX3_MOUSE P42581
We list detailed information on various proteins on this webpage, which EnkiLife references when developing protein-related products. The protein data is sourced from UniProt, and since UniProt updates its information periodically, the data on our webpage may not always be up-to-date or may contain inaccuracies. If you notice any errors while browsing, we warmly welcome your feedback. Additionally, if you have any suggestions regarding any aspect of our website, please feel free to share them with us. As a token of our appreciation, we will offer a free product or a discount voucher for purchases to scientists who provide feedback. Please contact us at Email: order@enkilife.com; to share your feedback and get your rewards.
UniProt:P42581
Recommended name：Homeobox protein HMX3
EC number：
Alternative names：(Homeobox protein H6 family member 3) (Homeobox protein Nkx-5.1)
Cleaved into：
GeneID：15373
Gene names (primary )：Hmx3
Gene names (synonym )：Nkx-5.1 Nkx5-1
Gene names (ORF )：
Length：356
Mass：37859
Sequence：MPEPGPDASGTASAPPPQPPPQPPAPKESPFSIRNLLNGDHHRPPPKPQPPPRTLFAPASAAAAAAAAAAAAAKGALEGAAGFALSQVGDLAFPRFEIPAQRFALPAHYLERSPAWWYPYTLTPAGGHLPRPEASEKALLRDSSPASGTDRDSPEPLLKADPDHKELDSKSPDEIILEESDSEEGKKEGEAVPGAAGTTVGATTATPGSEDWKAGAESPEKKPACRKKKTRTVFSRSQVFQLESTFDMKRYLSSSERAGLAASLHLTETQVKIWFQNRRNKWKRQLAAELEAANLSHAAAQRIVRVPILYHENSAAEGAAAAAGAPVPVSQPLLTFPHPVYYSHPVVSSVPLLRPV
Tissue specificity：Expressed in the developing CNS, including a specific expression in vestibular structures throughout inner ear development. {ECO:0000269|PubMed:11748138, ECO:0000269|PubMed:9389661, ECO:0000269|PubMed:9435283}.
Induction：Regulated by Six1 and FGFs in inner ear. {ECO:0000269|PubMed:11731242, ECO:0000269|PubMed:12874121, ECO:0000269|PubMed:14695375}.
Developmental stage：Begins at embryonic day 10.5 in the developing ear, hypothalamus, the neural tube and dorsal root ganglia. It continues to be active throughout prenatal life in discrete regions of the brain with an anterior border in the ventral diencephalon at the optic chiasma and expression domains in mesencephalon, metencephalon, and myelencephalon. At midgestation, it is also expressed in mesenchyme of the head and branchial arches, and in some cranial ganglia, as well as in derivatives of neural crest, such as the truncus sympathicus and myenteric ganglia. In inner ear, it is expressed between 13.5 dpc and birth in non-sensory epithelium of the semicircular canals, utricle and saccule. Also expressed in the cochlea, where the expression is restricted to the stria vascularis. {ECO:0000269|PubMed:11748138, ECO:0000269|PubMed:7510254, ECO:0000269|PubMed:8541222, ECO:0000269|PubMed:8970821}.
Protein families：HMX homeobox family