ERRFI_MOUSE Q99JZ7
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UniProt:Q99JZ7
Recommended name：ERBB receptor feedback inhibitor 1
EC number：
Alternative names：(Mitogen-inducible gene 6 protein homolog) (MIG-6)
Cleaved into：
GeneID：74155
Gene names (primary )：Errfi1
Gene names (synonym )：Mig6
Gene names (ORF )：
Length：461
Mass：50075
Sequence：MSTAGVAAQDIRVPLKTGFLHNGQALGNMKSCWGSHSEFENNFLNIDPITMAYNLNSPAQEHLTTVGCAARSAPGSGHFFAECGPSPRSSLPPLVISPSESSGQREEDQVMCGFKKLSVNGVCTSTPPLTPIKSCPSPFPCAALCDRGSRPLPPLPISEDLCVDEADSEVELLTTSSDTDLLLEDSAPSDFKYDAPGRRSFRGCGQINYAYFDSPTVSVADLSCASDQNRVVPDPNPPPPQSHRRLRRSHSGPAGSFNKPAIRISSCTHRASPSSDEDKPEVPPRVPIPPRPAKPDYRRWSAEVTSNTYSDEDRPPKVPPREPLSRSNSRTPSPKSLPSYLNGVMPPTQSFAPDPKYVSSKALQRQSSEGSANKVPCILPIIENGKKVSSTHYYLLPERPPYLDKYEKYFKEAEETNPSTQIQPLPAACGMASATEKLASRMKIDMGSHGKRKHLSYVVSP
Tissue specificity：Detected in lung, in airway epithelial cells and alveolar type 2 cells (at protein level). Detected in uterus stroma, luminal epithelium and glandular epithelium. {ECO:0000269|PubMed:16648858, ECO:0000269|PubMed:19710174}.
Induction：Up-regulated by lysophosphatidic acid (LPA) and sphingosine 1-phosphate. Up-regulated by globular actin monomers, via MKL1 signaling. Up-regulated in uterus in response to progesterone. Up-regulated in uterus in response to estrogen. Up-regulated in pregnant uterus. {ECO:0000269|PubMed:19439667, ECO:0000269|PubMed:19683494, ECO:0000269|PubMed:20018910}.
Developmental stage：Detected at low levels during embryogenesis. Strongly up-regulated during the first days after birth. Levels are increased on the first day after birth, and culminate three days after birth. Detected at low levels four days after birth, and throughout the remaining life span. {ECO:0000269|PubMed:19710174}.
Protein families：MIG6 family