KCNA2_MOUSE P63141
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UniProt:P63141
Recommended name：Potassium voltage-gated channel subfamily A member 2
EC number：
Alternative names：(MK2) (Voltage-gated potassium channel subunit Kv1.2)
Cleaved into：
GeneID：16490
Gene names (primary )：Kcna2
Gene names (synonym )：
Gene names (ORF )：
Length：499
Mass：56701
Sequence：MTVATGDPVDEAAALPGHPQDTYDPEADHECCERVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDENEDMHGGGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERDSQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYLQVTSCPKIPSSPDLKKSRSASTISKSDYMEIQEGVNNSNEDFREENLKTANCTLANTNYVNITKMLTDV
Tissue specificity：Detected in brain (PubMed:17634333). Detected in cerebellum (PubMed:20696761). Detected in mitral cells in the olfactory bulb (PubMed:8046438). Detected in cochlea (PubMed:23864368). Detected in cerebellum, particularly in the basket cell axon plexus and in the terminal regions around Purkinje cells (PubMed:8361541, PubMed:8046438, PubMed:18760366). Detected in juxtaparanodal regions in sciatic nerve (PubMed:22649228). Detected in Schwann cells from sciatic nerve (PubMed:9852577). Detected in dopamine neurons in substantia nigra (PubMed:21233214). Detected in large myelinated fibers in juxtaparanodes in the CA3 and CA1 areas of the hippocampus (PubMed:8046438, PubMed:18760366). Detected in brain, in punctae on fiber tracts in brain stem and spinal cord, and on axons in the juxtaparanodal regions of the node of Ranvier (at protein level) (PubMed:8361541). Detected in dopamine neurons in the midbrain (PubMed:21233214). {ECO:0000269|PubMed:17634333, ECO:0000269|PubMed:18760366, ECO:0000269|PubMed:20696761, ECO:0000269|PubMed:22649228, ECO:0000269|PubMed:23864368, ECO:0000269|PubMed:8046438, ECO:0000269|PubMed:8361541, ECO:0000269|PubMed:9852577}.
Induction：
Developmental stage：Detected at low levels in brainstem from neonates; increases tenfold during the first 29 days after birth. {ECO:0000269|PubMed:17634333}.
Protein families：Potassium channel family, A (Shaker) (TC 1.A.1.2) subfamily, Kv1.2/KCNA2 sub-subfamily