VSX2_MOUSE Q61412
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UniProt:Q61412
Recommended name：Visual system homeobox 2
EC number：
Alternative names：(Ceh-10 homeodomain-containing homolog) (Homeobox protein CHX10)
Cleaved into：
GeneID：12677
Gene names (primary )：Vsx2
Gene names (synonym )：Chx10
Gene names (ORF )：
Length：361
Mass：39436
Sequence：MTGKAGEALSKPKSETVAKSTSGGAPARCTGFGIQEILGLNKEPPSSHPRAALDGLAPGHLLAARSVLSPAGVGSMGLLGPGGLPGFYTQPTFLEVLSDPQSVHLQPLGRASGPLDTSQTASSDSEDVSSSDRKMSKSALNQTKKRKKRRHRTIFTSYQLEELEKAFNEAHYPDVYAREMLAMKTELPEDRIQVWFQNRRAKWRKREKCWGRSSVMAEYGLYGAMVRHSIPLPESILKSAKDGIMDSCAPWLLGMHKKSLEAAAESGRKPEVERQALPKLDKMEQEERAPEAQAAISQEELRENSIAALRAKAQEHSTKVLGTVSGPDSLARNAEKPEEEDATEEDRPAEKLSPPQLEDMA
Tissue specificity：Expressed in the retina (at protein level) (PubMed:8630490, PubMed:16547132, PubMed:17919464, PubMed:18417110, PubMed:19843539, PubMed:23028343). Expressed throughout the anterior optic vesicle and all neuroblasts of the optic cup (at protein level) (PubMed:8630490). In the mature and postnatal retina is restricted to the inner nuclear layer, in which its expression decreases from the outer to the inner margin (at protein level) (PubMed:8630490, PubMed:17919464, PubMed:19843539). Also detected in regions of the developing thalamus, hindbrain, and ventral spinal cord (PubMed:8630490). {ECO:0000269|PubMed:16547132, ECO:0000269|PubMed:17919464, ECO:0000269|PubMed:18417110, ECO:0000269|PubMed:19843539, ECO:0000269|PubMed:23028343, ECO:0000269|PubMed:8630490}.
Induction：
Developmental stage：Detected by embryonic day 25, by which time the optic cup has formed and the ganglion cell layer can be distinguished. A rapid increase to levels 3- to 4-fold greater than those seen in adult retina occurs in the period from birth (P0) to postnatal day 6 (P6). During this interval, the horizontal, bipolar, amacrine, and cone cells arise from the neuroretinal layer, the inner nuclear layer, and outer nuclear layer separate, and the outer plexiform layer begins to form. Levels begin to decrease by P8, when the rod outer segments are Still differentiating, and reaches its lowest levels in adult retina.
Protein families：Paired homeobox family