IMPCT_MOUSE O55091
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UniProt:O55091
Recommended name：Protein IMPACT
EC number：
Alternative names：(Imprinted and ancient gene protein)
Cleaved into：
GeneID：16210
Gene names (primary )：Impact
Gene names (synonym )：
Gene names (ORF )：
Length：318
Mass：36276
Sequence：MAEEEVGNSQRQSEEIEAMAAIYGEEWCVIDENAKIFCIRVTDFMDDPKWTLCLQVMLPSEYPGTAPPSYQLNAPWLKGQERADLSNSLEEIYVHNMGESILYQWVEKIRDALIQKSQITEPDPDVKKKTEEVEVESEEDPILEHPPENPVKTLDLKISEETQPETEELPPVAHGVPITDRRSTFQAHVAPVVCPEQVKLVLAKLYENKKIASATHNIYAYRIFCEDKQTFLQDCEDDGETAAGGRLLHLMEILNVKNVMVVVSRWYGGILLGPDRFKHINNCARNILVEKNFTNTPDESTKNLGKKKVKKDKKKNDH
Tissue specificity：Present in neurons in most areas of the brain. Present at high level in hypothalamus, particularly in the suprachiasmatic nucleus (at protein level) (PubMed:15937339, PubMed:18260151). Preferentially expressed in brain, with a weaker expression in other tissues (PubMed:9256468). {ECO:0000269|PubMed:15937339, ECO:0000269|PubMed:18260151, ECO:0000269|PubMed:9256468}.
Induction：Up-regulated after serum withdrawal during neuronal differentiation (PubMed:23447528). {ECO:0000269|PubMed:23447528}.
Developmental stage：Detected in embryos at 7, 11, 15, and 17 dpc. At 16 dpc, predominantly expressed in the central nervous system (at protein level). Strongly up-regulated during brain development from 17 dpc up to at least postnatal days 14 (at protein level). In N2a neuroblastoma cell line model and in primary cultures of hippocampal neurons, up-regulated during neuronal differentiation induced by serum reduction (at protein level). {ECO:0000269|PubMed:23447528, ECO:0000269|PubMed:9256468}.
Protein families：IMPACT family