PLPP3_MOUSE Q99JY8
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UniProt:Q99JY8
Recommended name：Phospholipid phosphatase 3
EC number：EC 3.1.3.-
Alternative names：(Lipid phosphate phosphohydrolase 3) (PAP2-beta) (Phosphatidate phosphohydrolase type 2b) (Phosphatidic acid phosphatase 2b) (PAP-2b) (PAP2b)
Cleaved into：
GeneID：67916
Gene names (primary )：Plpp3
Gene names (synonym )：Lpp3 Ppap2b
Gene names (ORF )：
Length：312
Mass：35216
Sequence：MQSYKYDKAIVPESKNGGSPALNNNPRKGGSKRVLLICLDLFCLFMAALPFLIIETSTIKPYRRGFYCNDESIKYPLKVSETINDAVLCAVGIVIAILAIITGEFYRIYYLKEKSRSTTQNPYVAALYKQVGCFLFGCAISQSFTDIAKVSIGRLRPHFLSVCDPDFSQINCSEGYIQNYRCRGEDSKVQEARKSFFSGHASFSMFTMLYLVLYLQARFTWRGARLLRPLLQFTLLMMAFYTGLSRVSDYKHHPSDVLAGFAQGALVACCIVFFVSDLFKTKTSLSLPAPAIRREILSPVDIIDRNNHHNMV
Tissue specificity：Detected in lung, cerebellum and heart atrium. {ECO:0000269|PubMed:12925589, ECO:0000269|PubMed:21319224}.
Induction：
Developmental stage：Display a characteristic dynamic and changing pattern of expression throughout the life cycle of the mouse (PubMed:12925589). Expression during early stages of development is specific of structures where multiple inductive interactions occur such as the limb buds, mammary gland primordia, heart cushions and valves among others (PubMed:19123136). Detected in a few cells of the extra-embryonic ectoderm of E6.5 embryos. By E7.5, starts to be strongly expressed in the anterior visceral endoderm, as well as in the extra-embryonic membranes. By E8.0 expression extends to a highly localized region around the node and appears at the tip of the allantois. At E8.5 predominantly expressed in the allantois, the developing gut, the pericardio-peritoneal canal and somites. In E9.5 embryos persists in the umbilical cord, and is also found in the chorionic region. In later mid-gestation embryos, present at high levels in the apical ectodermal ridge and mesenchyme of the limb buds, in the peripheral nervous system, cranial nerves, and mammary gland primordia (PubMed:12925589). {ECO:0000269|PubMed:12925589, ECO:0000269|PubMed:19123136}.
Protein families：PA-phosphatase related phosphoesterase family