MYBA_MOUSE P51960
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UniProt:P51960
Recommended name：Myb-related protein A
EC number：
Alternative names：(A-Myb) (Myb-like protein 1)
Cleaved into：
GeneID：17864
Gene names (primary )：Mybl1
Gene names (synonym )：Amyb
Gene names (ORF )：
Length：751
Mass：85728
Sequence：MAKRSRSEDEDDDLQYADHDYEVPQQKGLKKLWNRVKWTRDEDDKLKKLVEQHGTDDWTLIASHLQNRSDFQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSLIAKHLKGRIGKQCRERWHNHLNPEVKKSSWTEEEDRIIYEAHKRLGNRWAEIAKLLPGRTDNSIKNHWNSTMRRKVEQEGYLQDGIKSERSSSKLQHKPCATMDHLQTQNQFYIPVQIPGYQYVSPDGNCVEHVQTSAFIQQPFVDEDPDKEKKIKELELLLMSAENEVRRKRLPPQPGSFSSWSGSFLMDDSMSNTLNNLEEHTTEFYSMDENQTVSAQQNSPTKFLAVEANAVLSSLQTIPEFPRTLELIESDPVAWSDVTSFDLSDAAASPVKSTPVKLMRIQHNEGAMECQFNVSLVLEGKKNSRNGGDSEAIPLTSPNVVKFSTPPTISRKKKRIRVGQSAGSELGSASLSEVGNRRIKHTPVKTLPFSPSQFFNTCPGNEQLNIENPSFTSTPICGQKVLITTPLQKEATPKDQKENVGFRTPTIRRSILGTTPRTPTPFKNALAAQEKKYGPLKIVSQPLAFLEEDIREVLKEETGTDIFLKEEDEPAYKSCKQEHSASVKKVRKSLALESWDKEEPGTQLLTEDISDMQSENILTTSLLMIPLLEIHDNRCNLTPEKQDINSANKTYTLNKKRPNPNPCKAVKLEKSLQSNCEWETVVYGKTEDQLIMTEQARRYLSTYTATSSTSRALIL
Tissue specificity：Predominantly in the testis. Very low levels in the ovaries, spleen and brain. {ECO:0000269|PubMed:7813437, ECO:0000269|PubMed:8084617}.
Induction：
Developmental stage：During embryogenesis it is predominantly expressed in several regions of the developing central nervous system and the urogenital ridge. Expression in the CNS is confined to the neural tube, the hindbrain, the neural retina and the olfactory epithelium, and coincides with the presence of proliferating immature neuronal precursor cells. In the adult mouse, A-Myb is expressed at high levels in type A spermatogonia (stem cells), and preleptotene and pachytene spermatocytes, with concomitant down-regulation of expression upon terminal differentiation of these cells into mature spermatozoa, and in B lymphocytes located in germinal centers of the spleen (PubMed:7813437, PubMed:8084617). Present in mid-late pachytene and diplotene spermatocytes, but not in late zygotene/early pachytene cells (at protein level) (PubMed:21750041). {ECO:0000269|PubMed:21750041, ECO:0000269|PubMed:7813437, ECO:0000269|PubMed:8084617}.
Protein families：