NTCP7_MOUSE Q5PT53
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UniProt:Q5PT53
Recommended name：Sodium/bile acid cotransporter 7
EC number：
Alternative names：(Na(+)/bile acid cotransporter 7) (Solute carrier family 10 member 7)
Cleaved into：
GeneID：76775
Gene names (primary )：Slc10a7
Gene names (synonym )：P7
Gene names (ORF )：
Length：340
Mass：37256
Sequence：MRLLERARKEWFMVGIVVAIGAAKLEPSVGVNGGPLKPEITVSYIAVATIFFNSGLSLKTEELTSALVHLRLHLFIQIFTLAFFPAAIWLFLQLLSVTSINEWLLKGLQTVGCMPPPVSSAVILTKAVGGNEAAAIFNSAFGSFLGIVVTPVLLLLFLGSSSSVPFTSIFSQLFMTVVVPLVIGQIVRRYIKDWLERKKPPFGVVSSSVLLMIIYTTFCDTFSNPNIDLDKFSLILILFIIVSVQLSFMLLTFIFSTRNNSGFTPADTVAIIFCSTHKSLTLGIPMLKIVFAGHEHLSLISVPLLIYHPAQILLGSVLVPTIKSWMVSRQKGVKLTRPTV
Tissue specificity：Expressed in heart, brain, colon, lung, liver, adrenal gland, stomach and ovary. Also expressed weakly in small intestine. Expressed in skeletal tissues (PubMed:30082715). {ECO:0000269|PubMed:17628207, ECO:0000269|PubMed:30082715}.
Induction：
Developmental stage：Embryos at gestational age E12.5 show the weakest SLC10A7 expression, mainly in the heart trabeculae of the developing heart and the cartilage of the vertebrae. From day E14.5 onwards, expression becomes more ubiquitous, with the strongest level observed at day E16.5 and postnatal day P0. At E14.5, it is strongly expressed in cartilaginous structures in the mandible, in the epithelial compartment of cap stage teeth, in the digits, in the spine and in the lung. At E16.5, transcripts are mostly localized in the inner dental epithelium and in the epithelial loop of bell stage teeth. At E18.5 expression is observed in the inner dental epithelium of incisors, and in ameloblasts and odontoblasts of molars. At postnatal day P0 there is strong expression in the papillary layer of the oral mucous membrane underneath the palate, as well as in the ameloblast layer of emerging teeth. At postnatal day P10, it is localized to the growth plate of several long bones, such as the forefoot digits, the hindfoot tarsals and the humerus, and expression is more intense in the chondrocytes of the hypertrophic zone. {ECO:0000269|PubMed:30082715, ECO:0000269|PubMed:31191616}.
Protein families：Bile acid:sodium symporter (BASS) (TC 2.A.28) family