DDIT4_MOUSE Q9D3F7
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UniProt:Q9D3F7
Recommended name：DNA damage-inducible transcript 4 protein
EC number：
Alternative names：(Dexamethasone-induced gene 2 protein) (HIF-1 responsive protein RTP801) (Protein regulated in development and DNA damage response 1) (REDD-1)
Cleaved into：
GeneID：74747
Gene names (primary )：Ddit4
Gene names (synonym )：Dig2 Redd1 Rtp801
Gene names (ORF )：
Length：229
Mass：24871
Sequence：MPSLWDRFSSSSSSSSSSRTPAADRPPRSAWGSAAREEGLDRCASLESSDCESLDSSNSGFGPEEDSSYLDGVSLPDFELLSDPEDEHLCANLMQLLQESLSQARLGSRRPARLLMPSQLVSQVGKELLRLAYSEPCGLRGALLDVCVEQGKSCHSVAQLALDPSLVPTFQLTLVLRLDSRLWPKIQGLLSSANSSLVPGYSQSLTLSTGFRVIKKKLYSSEQLLIEEC
Tissue specificity：Ubiquitously expressed. {ECO:0000269|PubMed:12736248, ECO:0000269|PubMed:21383064}.
Induction：By dexamethasone, heat-shock or osmotic stress. Up-regulated by hypoxia, in a HIF1A-dependent but TP53-independent mechanism. Up-regulated upon energy stress. Up-regulated in brain from MPTP-intoxicated mice, a model for Parkinson disease (at protein level). Up-regulated by hypoxia in bowel, liver, spleen, heart, lung, brain and kidney. {ECO:0000269|PubMed:11884613, ECO:0000269|PubMed:12453409, ECO:0000269|PubMed:15452091, ECO:0000269|PubMed:15545625, ECO:0000269|PubMed:15988001, ECO:0000269|PubMed:17005863, ECO:0000269|PubMed:21383064}.
Developmental stage：Expressed at 7 dpc. At 11 dpc, expressed in the apical ectodermal ridge. At 13.5 dpc, expressed in the whisker pad, eyelid, breast primordia and developing limb. At 14.5 dpc, expressed in supraorbital and suborbital follicles, whisker pad, limbs and patches of developing epidermis. {ECO:0000269|PubMed:12453409, ECO:0000269|PubMed:12736248}.
Protein families：DDIT4 family