NFAC4_MOUSE Q8K120
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UniProt:Q8K120
Recommended name：Nuclear factor of activated T-cells, cytoplasmic 4
EC number：
Alternative names：(NF-ATc4) (NFATc4) (T-cell transcription factor NFAT3) (NF-AT3)
Cleaved into：
GeneID：73181
Gene names (primary )：Nfatc4
Gene names (synonym )：Nfat3
Gene names (ORF )：
Length：901
Mass：95782
Sequence：MGAASCEDEELEFKLVFGEEKEPPPLGPGGPGEELDSEDTPPCCRLALGEPLPYGAAPIGIPRPPPPRPGMHSPPPRPAPSPGTWESQPARSVRLGGPGGNAGGAGGGRVLECPSIRITSISPTPDPPTSLEDTSETWGDGSPRDYPPPEGFGGYREAGGQGGGAFFSPSPGSSSLSSWSFFSDASDEAALYAACDEVESELNEAASRFGLSSPLPSPRASPRPWTPEDPWSLYGPSSGGRAPEDSWLLLSAPGPVPASPRPASPCGKRRYSSSGTPSSASPALSRRGSLGEEGPEPPPPPPLPLVRDPSSPGPFDYVGAPPTESIPQKTRRTSSEQAVALPRSEEPPSCNGKLPSGTEDSVAAPGALRKEVAGMDYLAVPSPLAWSKARIGGHSPIFRTSALPPLDWPLPSQYEQLELRIEVQPRAHHRAHYETEGSRGAVKAAPGGHPVVKLLGYSEKPLTLQMFIGTADERSLRPHAFYQVHRITGKMVATASYEAVVSGTKVLEMTLLPENNMAANIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHVPQGGGKVVSVQAASVPIECSQRSAQELPQVETYSPSACSVRGGEELVLTGSNFLPDSKVVFIERGPDGKLQWEEEAAVNRLQSSEVTLTLTIPEYSNKRVSRPVQVYFYVSNGRRKRSPTQSFKFLPVVFKEEPLPDSSLRGFPSTSGPPFGPDVDFSPPRPPYPSYPHEDPAYETPYLSEGFGYSTPALYPQTGPPPSYRSGLRMFPETGGTTGCARLPSVSFLPRPFPGDQYGGQGSSFALGLPFSPPAPFRPPLPSSPPLEDPFHPQSAIHPLPPEGYNEVGPGYTPGEGASEQEKARGGYSSGFRDSVPIQGITLEEVSEIIGRDLSGFPARPGEEPPA
Tissue specificity：Widely expressed (PubMed:18675896). In the brain, expressed in neurons (PubMed:18675896, PubMed:25663301). Expressed in the hippocampus (at protein level) (PubMed:25663301). In the hippocampus, expressed in both the CA1-CA3 pyramidal cells and the dentate gyrus granular cells (PubMed:22586092). Expressed in a subset of hippocampal cells representing adult-born neurons (at protein level) (PubMed:22586092). In the olfactory system, expressed at low levels in the glomerular and granular layers and in the mitral cell layer (PubMed:18675896). In the cerebellum, expressed at moderate levels in granular neurons (PubMed:18675896). Expressed at moderate levels in the choroid plexus and ependymal cells (PubMed:18675896). Expressed in neurons of the cochlear nucleus (at protein level) (PubMed:18354019). Expressed at low levels in the heart (at protein level) (PubMed:12370307). {ECO:0000269|PubMed:12370307, ECO:0000269|PubMed:18354019, ECO:0000269|PubMed:18675896, ECO:0000269|PubMed:22586092, ECO:0000269|PubMed:25663301}.
Induction：Up-regulated by BDNF. {ECO:0000269|PubMed:22586092}.
Developmental stage：Expressed at high levels in the embryonic brain at 13.5 dpc (PubMed:18675896, PubMed:22586092). Expression decreases thereafter, reaching the lowest levels at postnatal day 14 and remaining unchanged in adulthood (PubMed:18675896). Expressed in the developing heart at 13.5 and 16.5 dpc, during the transition from spongy to compact myocardium (PubMed:17198697). {ECO:0000269|PubMed:17198697, ECO:0000269|PubMed:18675896, ECO:0000269|PubMed:22586092}.
Protein families：