NFAC1_MOUSE O88942
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UniProt:O88942
Recommended name：Nuclear factor of activated T-cells, cytoplasmic 1
EC number：
Alternative names：(NF-ATc1) (NFATc1) (NFAT transcription complex cytosolic component) (NF-ATc) (NFATc)
Cleaved into：
GeneID：
Gene names (primary )：Nfatc1
Gene names (synonym )：Nfat2 Nfatc
Gene names (ORF )：
Length：717
Mass：77833
Sequence：MPNTSFPVPSKFPLGPPAAVCGSGETLRPAPPSGGTMKAAEEEHYSYVSPSVTSTLPLPTAHSALPAACHDLQTSTPGISAVPSANHPPSYGGAVDSGPSGYFLSSGNTRPNGAPTLESPRIEITSYLGLHHGSGQFFHDVEVEDVLPSCKRSPSTATLHLPSLEAYRDPSCLSPASSLSSRSCNSEASSYESNYSYPYASPQTSPWQSPCVSPKTTDPEEGFPRSLGACHLLGSPRHSPSTSPRASITEESWLGARGSRPTSPCNKRKYSLNGRQPSCSPHHSPTPSPHGSPRVSVTEDTWLGNTTQYTSSAIVAAINALTTDSTLDLGDGVPIKSRKTALEHAPSVALKVEPAGEDLGTTPPTSDFPPEEYTFQHLRKGAFCEQYLSVPQASYQWAKPKSLSPTSYMSPSLPALDWQLPSHSGPYELRIEVQPKSHHRAHYETEGSRGAVKASAGGHPIVQLHGYLENEPLTLQLFIGTADDRLLRPHAFYQVHRITGKTVSTTSHEIILSNTKVLEIPLLPENNMRAIIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPNGRTLSLQVASNPIECSQRSAQELPLVEKQSTDSYPVIGGKKMVLSGHNFLQDSKVIFVEKAPDGHHVWEMEAKTDRDLCKPNSLVVEIPPFRNQRITSPAQVSFYVCNGKRKRSQYQRFTYLPANGNSVFLTLSSESELRGGFY
Tissue specificity：Expressed in spleen, lung, skeletal muscle, thymus and skin (PubMed:9388475). Weakly expressed in heart, brain, liver and kidney. Not expressed in testis (PubMed:10072529). {ECO:0000269|PubMed:10072529, ECO:0000269|PubMed:9388475}.
Induction：Inducibly expressed in T-lymphocytes upon activation of the T-cell receptor (TCR) complex. Induced after addition of phorbol 12-myristate 13-acetate (PMA) (PubMed:9388475, PubMed:10072529). Expressed during osteoclastogenesis and its induction and activation is regulated by TNFSF11 (PubMed:26644563). {ECO:0000269|PubMed:10072529, ECO:0000269|PubMed:26644563, ECO:0000269|PubMed:9388475}.
Developmental stage：Expressed at low levels at 7 dpc and increases until 17 dpc. At 17 dpc, strongly expressed in thymus, lung and submandibular gland and weakly in skeletal muscle and heart (PubMed:9388475). Expressed in the developing heart at 13.5 and 16.5 dpc, during the transition from spongy to compact myocardium (PubMed:17198697). {ECO:0000269|PubMed:17198697, ECO:0000269|PubMed:9388475}.
Protein families：