FOXN4_MOUSE Q8K3Q3
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UniProt:Q8K3Q3
Recommended name：Forkhead box protein N4
EC number：
Alternative names：
Cleaved into：
GeneID：116810
Gene names (primary )：Foxn4
Gene names (synonym )：
Gene names (ORF )：
Length：521
Mass：56121
Sequence：MIESGIWSRMSEMIRSSGHSHHCSPQEYRFLPPVGDDDLPGDLQSLSWLTAVDVPRLQQMANGRIDLGSSGVTHPHPGALAGTADLHVGAAPRPLLRRSQTAVVPRGVLGLSPIGNHRASAEQMNQFPAGGQASSGLQEMPQLYSPATQIPFPLPLGSQQCPPAGLYGSPFSARPSYPQAHGAMHASQEPHPKHYPKPIYSYSCLIAMALKNSKTGSLPVSEIYSFMKEHFPYFKTAPDGWKNSVRHNLSLNKCFEKVETKSSGSSRKGCLWALNLARIDKMEEEMHKWKRKDLAAIHRSMANPEELDKLISDRPESCRRPGKRGEPKAPMLTHATTVAMAHSCLAISQLPPKPLMTLSLQSVPLHHQLQPQAHLAPDSPAPAQTPPLHALPSLSPGPLPQPAMGRVPGDFLNINSDMNTEVDALDPSIMDFALQGNLWEEMKEDSFSLDTLEAFGDSPLGCDLGAPSLTPVSGNSDQSFPDVQVTGLYAAYSTAADGVAPSAANSAQYLGTPGNKPIALL
Tissue specificity：Mainly expressed in proliferator progenitor cells in brain and retina rather than differentiated cells. In contrast, is expressed only in postmitotic epithelial cells rather than in proliferative progenitors in the proximal airway. {ECO:0000269|PubMed:15363391, ECO:0000269|PubMed:16020526, ECO:0000269|PubMed:21438071}.
Induction：
Developmental stage：Expressed in both neural and non-neural tissues of the embryo. In the nervous system, its expression is detected only in a few selected central nervous system tissues including the midbrain, hindbrain, spinal cord and retina while absent from the peripheral nervous system. At about 9.5 dpc-10.5 dpc, commences its expression in the dorsal mesenphalon, ventral rhombencephalon and ventral spinal cord. In the spinal cord, is found in p2 progenitor cells but not in mature V2a and V2b cells, in other interneuron subtypes or in motoneurons. The expression in the brain and spinal cord becomes weak at 12.5 dpc and disappears by 13.5 dpc. In the central eye, expression starts in the central retina at 11.5 dpc, then gradually becomes abundant in the entire retinal outer neuroblastic layer by 13.5 dpc, but is absent from the inner neuroblastic layer. Starting from P1 and by P7, the expression in the retina gradually disappears from the center to the periphery. In airway system, expression turns on at 14.5 dpc in a small set of cells in the epithelia of the trachea and esophagus, then spreads to the epithelia of bronchi and bronchioles by 15.5 dpc, the expression persists until at least P8 (at protein level). {ECO:0000269|PubMed:15363391, ECO:0000269|PubMed:16020526, ECO:0000269|PubMed:17728344, ECO:0000269|PubMed:21438071, ECO:0000269|Ref.1}.
Protein families：