CRUM2_MOUSE Q80YA8
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UniProt:Q80YA8
Recommended name：Protein crumbs homolog 2
EC number：
Alternative names：(crumbs2) (Crumbs-like protein 2)
Cleaved into：
GeneID：241324
Gene names (primary )：Crb2
Gene names (synonym )：
Gene names (ORF )：
Length：1282
Mass：134760
Sequence：MALVGPRIWGPRRDIYPLLLLLLLLLLLLLPWVPAGLVPPETPSVCASDPCAPGTKCQATESGGYTCEPSELGGCATQPCHHGALCVPQGPDPNSFRCYCVPGFQGPHCELDIDECASRPCQHGGTCQNLADHYECHCPLGYAGVTCEAEVDECSSAPCLHGGSCLDGVGSYRCVCAPGYAGANCQLDVDECQSQPCAHGGVCHDLVNGFRCDCADTGYEGARCEQEVLECASAPCAHNASCLDGFRSFRCLCWPGFSGERCEVDEDECASGPCQNGGQCLQRSDPTLYGGVQAIFPGAFSFSHAAGFLCSCPLGFAGNDCSMDVDECASGPCLNGGSCQDLPNGFQCYCQDGYTGLTCQEDMDECQSEPCLHGGTCSDTVAGYICQCPEAWGGHDCSVQLTGCQGHTCPLAATCIPTFKSGLHGYFCRCPPGTYGPFCGQNTTFSVVSGSSVWGLVPAAASLGLALRFRTTLLAGTLATLKDTRDSLELVLVGAVLQATLSRHGTAVLILTLPDLALNDGHWHQVEVTLHLGTLELRLWHEGCPGQLCVASGPVATGPTASVASGPPGSYSIYLGGGVFAGCFQDVRVEGHLLLPEELKGTVLLGCERREPCQPLPCAHGGACVDLWTHFRCDCPRPYRGATCTDEVPAATFGLGGATSSASFLLHQLGPNLTVSFFLRTREPAGLLLQFANDSVASLTVFLSEGQIRAEGLGHPAVVLPGRWDDGLPHLVMLSFGPDQLQDLGQRLYVGGRFYPDDTQLWGGPFRGCLQDLQLNSIHLPFFSSPMENSSWPSELEAGQSSNLTQGCVSEDTCNPNPCFNGGTCHVTWNDFYCTCSENFTGPTCAQQRWCPRQPCLPPATCEEVPDGFVCVAEATFREGPPAVFTGHNVSSSLSGLTLAFRTRDSEAGLLRAVSAAGAHSNIWLAVRNGSLAGDVAGSVLPAPGPRVADGAWHRVRLAREFPQAAASRWLLWLDGAATPVALHGLGGDLGFLQGPGAVPLLLAENFTGCLGRVALGDFPLPLAPPRSGTVSGAREHFVAWPGSPAVSLGCRGGPVCSPSPCLHGGACRDLFDAFACSCGPAWEGPRCEIRADPCRSTPCVRGQCHARPDGRFECRCPPGFSGPRCRLPVLPQGCNLNSTCKDGAPCEGGPLGTNCSCQEGLAGLRCQSLDKPCEASPCLNGGTCRVASGIFECTCSAGFSGQFCEVVKTLPLPLPFPLLEVAVPAACACLLLLLLGLLSGILAARKRRQSEGTYSPSQQEVAGARLEMDSVLKVPPEERLI
Tissue specificity：In the adult eye, strongly expressed in the outer nuclear layer, containing the cell bodies of the photoreceptor cells, and in the inner nuclear layer, containing the cell bodies of the horizontal, bipolar, amacrine, and Mueller glial cells (PubMed:15851977). Also expressed in some cells in the ganglion cell layer (or may be displaced amacrine cells rather than ganglion cells) (PubMed:15851977). {ECO:0000269|PubMed:15851977}.
Induction：
Developmental stage：Expressed in early embryonic cells, more specifically in embryonic regions undergoing dramatic rearrangement, such as the developing neuroepithelium which proceeds with neural tube closure, the anterior splitting lateral plate mesoderm that wraps the pericardial cavity and the differentiating somite epithelium (PubMed:22072575). Widely expressed throughout the epiblast and the lateral plate mesoderm at 7 dpc. At 7.5 dpc-7.75 dpc, continues to be expressed in these regions, and expression is also found on the apical side of the embryonic endoderm, and extraembryonic amnion and allantois (PubMed:22072575). At 8-8.5 dpc, expression is also detected in the heart tube, foregut and the apical side of the somite epithelium (PubMed:22072575). Stronger expression is detected on the apical sides of the splitting lateral plate mesoderm, and the apical side of the neural ectoderm at trunk region (PubMed:22072575). Not expressed in the notochord plate or the extra-embryonic endoderm (PubMed:22072575). Expressed in the developing spinal cord, eye, and forebrain at 10.5 dpc (PubMed:17920587). Expressed in the ventricular layers of the developing neural tube along the entire cranial-caudal length, including the anterior forebrain and the posterior spinal cord at 11.5 dpc (PubMed:17920587). Expressed in apical epithelial kidney cells at 15.5 dpc (PubMed:17920587). {ECO:0000269|PubMed:17920587, ECO:0000269|PubMed:22072575}.
Protein families：Crumbs protein family