NDF1_MOUSE Q60867
We list detailed information on various proteins on this webpage, which EnkiLife references when developing protein-related products. The protein data is sourced from UniProt, and since UniProt updates its information periodically, the data on our webpage may not always be up-to-date or may contain inaccuracies. If you notice any errors while browsing, we warmly welcome your feedback. Additionally, if you have any suggestions regarding any aspect of our website, please feel free to share them with us. As a token of our appreciation, we will offer a free product or a discount voucher for purchases to scientists who provide feedback. Please contact us at Email: order@enkilife.com; to share your feedback and get your rewards.
UniProt:Q60867
Recommended name：Neurogenic differentiation factor 1
EC number：
Alternative names：(NeuroD1) (Beta-cell E-box transcriptional activator 2) (Beta2)
Cleaved into：
GeneID：18012
Gene names (primary )：Neurod1
Gene names (synonym )：Neurod
Gene names (ORF )：
Length：357
Mass：39999
Sequence：MTKSYSESGLMGEPQPQGPPSWTDECLSSQDEEHEADKKEDELEAMNAEEDSLRNGGEEEEEDEDLEEEEEEEEEEEDQKPKRRGPKKKKMTKARLERFKLRRMKANARERNRMHGLNAALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRSGKSPDLVSFVQTLCKGLSQPTTNLVAGCLQLNPRTFLPEQNPDMPPHLPTASASFPVHPYSYQSPGLPSPPYGTMDSSHVFHVKPPPHAYSAALEPFFESPLTDCTSPSFDGPLSPPLSINGNFSFKHEPSAEFEKNYAFTMHYPAATLAGPQSHGSIFSSGAAAPRCEIPIDNIMSFDSHSHHERVMSAQLNAIFHD
Tissue specificity：Expressed in pancreatic beta cells, pulmonary neuroendocrine cells and retinal interneurons amacrine cells (at protein level). Expressed in endocrine cells of the pancreas. Expressed in the inner layer of cerebellar external granular layer (EGL). Expressed in the Ammon's horn (AH), which includes the CA1-CA3 pyramidal layer and in granule cells of the dentate gyrus (DG). Expressed in photoreceptors of the outer nuclear layer (ONL), in a subset of cells in the lower half of the inner nuclear layer (INL), and in a subset of cells in the ganglion cell layer (GCL) of the retina. Expressed in cholinergic and AII amacrine cell types. Expressed in differentiating neurons of both the central and peripheral nervous systems. {ECO:0000269|PubMed:10398678, ECO:0000269|PubMed:11861467, ECO:0000269|PubMed:12810726, ECO:0000269|PubMed:14752053, ECO:0000269|PubMed:19759004, ECO:0000269|PubMed:9308961}.
Induction：Up-regulated by NKX2-2 and NEUROG3. {ECO:0000269|PubMed:19759004, ECO:0000269|PubMed:19854889}.
Developmental stage：Expressed in glucagon- and ghrelin-producing cells of the pancreas at 14.5 dpc. Expressed in each of the hormone-producing cells population of the pancreas, except somatostatin-producing cells at 16.5 dpc (at protein level). Expressed during embryonic development. Expressed in the earliest islet precursor cells of the pancreas at 9.5 dpc. Expressed in neuronal cells in the inner ear between 9.5 and 12.5 dpc. Expressed within the otic epithelium and among the delaminating cells migrating away from the ear to form sensory neurons at 10.5 dpc. Expressed in the upper blade of the nascent dentate gyrus at 16.5 dpc. {ECO:0000269|PubMed:10639171, ECO:0000269|PubMed:11152640, ECO:0000269|PubMed:11970861, ECO:0000269|PubMed:21593321, ECO:0000269|PubMed:9308961}.
Protein families：