ANK2_MOUSE Q8C8R3
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UniProt:Q8C8R3
Recommended name：Ankyrin-2
EC number：
Alternative names：(ANK-2) (Ankyrin-B) (Brain ankyrin)
Cleaved into：
GeneID：109676
Gene names (primary )：Ank2
Gene names (synonym )：AnkB
Gene names (ORF )：
Length：3898
Mass：426261
Sequence：MMNEDAAQKSDSGEKFNGSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERKAPLLARTKNGLSPLHMAAQGDHVECVKHLLQYKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNTVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADRDAYTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTVTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAMIDDTVVIPSHQVSALAKEAERNSYRLSWGTENLDNVALSSSPIHSGFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVGPSGAQFLGPVIVEIPHFAALRGKERELVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVSQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVAFASQVYREIICVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFSEVARSRDVEVLEGKPIYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLPIYAKESESDQEPEEEIGMTSEKNDETESTETSVLKSHLVNEVPVLASPDLLSEVSEMKQDLIKMTAILTTDVSDKAGSLKVKELAKAGEEEPGEPFEIVERVKEDLEKVNAILRSGTCMRDEGRARSSQSERELEEEWVIVSDEEIQEAKQHAPVEIDEHPCIEVRVDRETKAKVEKDSTGLVNYLTDDLNSYTSPHEKKPHTAPEKSGETSQASAVGKSSESNKGKATSAEEKQSAQKQLKPGLAIKKPVRRKLKEKQKQKEESSQSSEEKTELKKGSSEESVDEDRGLVPEPLPTAKATSPLIEETPIGSIKDKVKALQKRVEDEQKGRSKLPVRVKGKEDVPKRTTPRTHPAVSPSSKSSTSSKAERHSSLSSSAKPERHTPVSPSSKNEKLSPVSPSAKTERHSPVFSGKPEKHSPGSPSTKNERHSPVSSLKTERHTPGSPSGKTDKRPPVPSSGRTEKHPPVSPGKTEKHLPGSPSIRTPEKPAPGSATGKHEKHLPVSPGKTEKQPPISPTSKTERIEETMSVRELMKAFQSGQDPSKHKTGLFEHKSAKQKQPQDKSKSRVEKEKGHTVTQREVTQRETQRIESQTAKRGQRFQVSAATESRRFRSTTITVGLRMEDPVRERFERTPIIKTPEVVPSVAAEESHRGSEKIVDEQGDMDFQISPDRKTSTDFSEVIKQELEDNDKYQQFRLTEDTEKAQVHLDQVITSPFNTAFPLDYMKDEFLPALSLQSGALGGSSESLKQEVIAGSPCSSLMEGTPQISSEESYKHEGLAETPETSPESLSFSPKKSEEQIGEAKETTKVGTPTDIHSEKELPITNDITDSSQKQGAGVTRGSEPSTEHSQKEVTQDPHKDVCSKQDGCPESQSVSLASEVFTEKGSCGESQLPLVSSAFKTQSESETQESLTPSEVTKPFPPSDASVKTAEGTEPKPQGAIRSPQGLELPLPNRDSEVLSPMADESLAVSHKDSLEASPVLEDNSSHKTPDSLEPSPLKESPCRDSLESSPVEPKMKAGILPSHFPLPAAIAKTDLVAEVASMRSRLLRDPDGSAEDDSLEQTSLMESSGKSPLSPDTPSSEEVSYEVTPKPSDSSTPKPAVIHECAEEDDSENGEKKRFTPEEEMFKMVTKIKTFDELEQEAKQKRDYKKEPRQDGSSSASDPDADYSAEVNDEKQMAGTEGEGEVPVLVTSENRKVSSSSSESEPELTQLSKGADSGLLTEPVIRVQPPSPLPSSIDSNSSPEEATQFQPIVPKQYTFKMNEEIQEEPATSEDKDCKSHLAEDSQTHSADAADGSDGDLNRETTQPETCDGHGCETVSPSNSATPVSLGVQSPEHKDVDKPLAIDKDSLAHQDTCENDREEREFDPSGVESTQADLPNESSSLSSRCAIPEGNESAKEIASPSSPVKVEVTITDQALESMPEDCPIQDSSTTMQTERFAMDVPVSELAETDENSDPQIISPYENVPSSSFFSAEPSKIQTDTCHSTVVHSPEVYSVIIRSSPEDVVVTNSSNRTVSGEESHCESHDLETESEQKSALWAAQSDAPPLAVAPTASDAASVTGEQASKVIITKTDADADSWSEIREDDAAFEARVKEEEQKIFGLMVDRQSQGTTPDTTPARTPTEEGTPTSEQNPFLFQEGKLFEMTRSGAIDMTKRPYADESLHFFQIGQESNEEAISEDLKEGATGAEPPQTETTSESLELSEPKEAMDDEGELLPDDVSEEIEDLPASDANIDSQVIISASTETPTKEAVSTAVEEPPTTQRSDSLSTVKQTPRPAVPGPVGQLDFSPVTRSVYSGQDDESPESSPEEQKSVIEIPTAPVDNVPSAESKPQIPIRTLPTLVPAPPSAEDESAFSDDFPSSLDEDSKEGGAKPKSKIPVKAPTQRTEWQPSPTDIPLQKTAVPQGQETLSRAPDGRSKSESDASSLDAKTKCPVKARSYIETETESRERAEGFESESEDGATKPKLFASRLPVKSRSTSSSGRPGTSPTRESREHFFDLYRNSIEFFEEISDEASKLVDRLTQSEREQEPPSDDESSSALEVSVIESLPPVDIEHSAPEDIFDTRPIWDESIETMIERIPDENGHDRAEDPQDEQERMEERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGKHATDTILIECLTKINRMDIVHLLETNTEPLQERMGRSYAEIEQTITLDHSEGFSVLPDELCAAKEKKEQEASKESESSDHPPMVSEEDISVGYSTFQDCLPKTEGDSPAAALSPQMHQEPVQQDFSGKTQDQQEYYVTTPGAEVEDPQKATAVPDSLCKTPEDISTPPEGTKPCLQTPVTSERGSPIVQEPEEASEPKEESSPRKTSLVIVESTDDQSQVFERLDGDAAFQKGDDMPDIPPETVTEEEYVDENGHTVVKKVTRKIIRRYVSSDGTEKEEVTMQGMPQEPVNIEDGDNYSKVIKRVVLKSDTQQSEDNNE
Tissue specificity：Detected in eye lens fiber cells (at protein level) (PubMed:21745462). In the retina, expressed in the inner segments of rod photoreceptors (PubMed:19007774). Expressed in cardiomyocytes, as well as in skeletal muscles (PubMed:17940615, PubMed:27718357, PubMed:12571597). Also detected in brain and pancreas, as well as in kidney and spleen (at protein level) (PubMed:8253844, PubMed:17940615, PubMed:12571597). In the pancreas, highly expressed in islets, predominantly in beta cells, but low expression, if any in acinar cells (at protein level) (PubMed:17940615). In the central nervous system, expressed in the corpus callosum and in cerebellar Purkinje neurons (at protein level) (PubMed:17940615, PubMed:27718357). Expressed in lung and, at low levels, in testes (at protein level) (PubMed:17940615). {ECO:0000269|PubMed:12571597, ECO:0000269|PubMed:17940615, ECO:0000269|PubMed:19007774, ECO:0000269|PubMed:21745462, ECO:0000269|PubMed:27718357, ECO:0000269|PubMed:8253844}.
Induction：
Developmental stage：Expressed in neonatal developing ventricular cardiomyocytes as well as adult cardiomyocytes. {ECO:0000269|PubMed:15262991}.
Protein families：