NKG2D_MOUSE O54709
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UniProt:O54709
Recommended name：NKG2-D type II integral membrane protein
EC number：
Alternative names：(Killer cell lectin-like receptor subfamily K member 1) (NK cell receptor D) (NKG2-D-activating NK receptor) (CD antigen CD314)
Cleaved into：
GeneID：27007
Gene names (primary )：Klrk1
Gene names (synonym )：Nkg2d
Gene names (ORF )：
Length：232
Mass：26710
Sequence：MALIRDRKSHHSEMSKCHNYDLKPAKWDTSQEQQKQRLALTTSQPGENGIIRGRYPIEKLKISPMFVVRVLAIALAIRFTLNTLMWLAIFKETFQPVLCNKEVPVSSREGYCGPCPNNWICHRNNCYQFFNEEKTWNQSQASCLSQNSSLLKIYSKEEQDFLKLVKSYHWMGLVQIPANGSWQWEDGSSLSYNQLTLVEIPKGSCAVYGSSFKAYTEDCANLNTYICMKRAV
Tissue specificity：Expressed in natural killer (NK) cells, activated CD8(+) alpha-beta and gamma-delta T-cells and natural killer T (NKT) cells (at protein level). May be expressed on dendritic cell (DC). Isoform 1 is strongly expressed in natural killer (NK) cells. Isoform 2 is weakly expressed in natural killer (NK) cells. Isoform 1 and isoform 2 are expressed in stimulated, but not in unstimulated, CD8(+) T-cells and macrophages. {ECO:0000269|PubMed:11248803, ECO:0000269|PubMed:11567106, ECO:0000269|PubMed:12150888, ECO:0000269|PubMed:15048723}.
Induction：Up-regulated in activated CD8(+) T-cells. Up-regulated upon lipopolysaccharide (LPS) and interferon treatments in macrophages. Up-regulated in CD8(+) T-cell infiltring pancreatic islets of prediabetic nonobese diabetic (NOD) mice (at protein level). Isoform 1 and isoform 2 are up-regulated upon T-cell receptor (TCR) stimulation in CD8(+) T-cells. Isoform 1 is modestly up-regulated upon lipopolysaccharide (LPS) in macrophages. Isoform 2 is up-regulated upon lipopolysaccharide (LPS) in macrophages. Isoform 2 is up-regulated upon poly(I:C) and interleukin IL2 in natural killer (NK) cells. {ECO:0000269|PubMed:12150888, ECO:0000269|PubMed:15189740}.
Developmental stage：Expressed in NK cells from the thymus at 15 dpc (at protein level). {ECO:0000269|PubMed:12150888}.
Protein families：