DMRT2_MOUSE Q8BG36
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UniProt:Q8BG36
Recommended name：Doublesex- and mab-3-related transcription factor 2
EC number：
Alternative names：(Doublesex-like 2 protein) (Terra)
Cleaved into：
GeneID：226049
Gene names (primary )：Dmrt2
Gene names (synonym )：
Gene names (ORF )：
Length：561
Mass：61641
Sequence：MTEGQAVPGVGDWEIDVESLDLEEDSCGTPLRATPPQEPSPAAADGEEDEDEEEEDEDVEDEGDGEEPGVSSEVPGRPEQPGGLAPRPPPAAQALPAAAAAPERGATAGGGAEPRKLSRTPKCARCRNHGVVSCLKGHKRFCRWRDCQCANCLLVVERQRVMAAQVALRRQQATEDKKGLSGKQNNFDRKAVYQRQVRAPSLLAKSILEGYRPMTAETYLGGTLPLPPPVSDRMRKRRAFADKELENIMLEREYKEREMLETSQAAALFLPNRMVPGPEYSSYKGTYSPTAGELPSKDFCNFLPTCLDLTMQYSGSGNMELISSNVSVATTYRQYPLSSRFLVWPKCGPISDTLLYQQYLLNATTSVQALKPGTGWDLKGTRVQDGLSAEQDMMPPKLEGSLVLPHLPEVPASRTDLQVHQVVPERSAFSPPGRNFSPIVDMDCLAAQGHVLTKLSKENTRPSLPLKTNPFHSVFQQTLSDKSGPELNAPFVKEAFEETPKKHRECLVKESQKYTFTIDRCAKDLFVAKQVGTKLSANEPLSFSVESILKRPSSAVTHVSQ
Tissue specificity：Expressed in testis. {ECO:0000269|PubMed:12609607, ECO:0000269|PubMed:20368965}.
Induction：Transcriptionally up-regulated by PAX3 within the dermomyotome. {ECO:0000269|PubMed:20368965}.
Developmental stage：Expressed in presomitic mesoderm and developing somites at 8.5 dpc, accumulating in the epaxial domain at 9.5 dpc in the immature caudal somites. At 10.5 dpc expressed in the dermomyotome of somites. By 11.5 dpc, only detectable in caudal somites. In mature somites, expression is confined to the dermomyotome of the somite where Pax3 is also expressed and in the epaxial domain of the most immature caudal somites. At this stage, the most mature anterior somites are beginning to lose the expression at the epaxial and hypaxial extremities of the dermomyotome. At 14.5 dpc expressed in testis, heart and brain. Expression is also detected in proximal forelimb buds and branchial arches of the developing embryo. {ECO:0000269|PubMed:10021344, ECO:0000269|PubMed:12609607, ECO:0000269|PubMed:16387292, ECO:0000269|PubMed:20368965}.
Protein families：DMRT family