ATF5_MOUSE O70191
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UniProt:O70191
Recommended name：Cyclic AMP-dependent transcription factor ATF-5
EC number：
Alternative names：(cAMP-dependent transcription factor ATF-5) (Activating transcription factor 5-alpha/beta) (BZIP protein ATF7) (NAP1) (NRIF3-associated protein) (Transcription factor ATFx) (Transcription factor-like protein ODA-10)
Cleaved into：
GeneID：107503
Gene names (primary )：Atf5
Gene names (synonym )：Atfx Nap1
Gene names (ORF )：
Length：283
Mass：30331
Sequence：MSLLATLGLELDRALLPASGLGWLVDYGKLPLAPAPLGPYEVLGGALEGGLPGGGEPLAGDGFSDWMTERVDFTALLPLEAPLPPGTLPPPSPAPPDLEAMASLLKKELEQMEDFFLDAPLLPPPSPPPPPPPAAAPSLPLPLPLPTFDLPQPPTLDTLDLLAVYCRSEAGPGDSGLSTLPVPQQPPPLAPLPSPARPAPYPSPASTRGDRKQKKRDQNKSAALRYRQRKRAEGEALEGECQGLEARNRELRERAESVEREIQYVKDLLIEVYKARSQRTRST
Tissue specificity：Highly expressed in liver and at lower levels in heart, brain, lung, kidney, adipose tissue, and skeletal muscle. Expressed in some immature and in all mature olfactory sensory neurons (at protein level) (PubMed:23090999). {ECO:0000269|PubMed:11278933, ECO:0000269|PubMed:12213205, ECO:0000269|PubMed:23090999}.
Induction：Expressed in a circadian manner in the liver. Down-regulated by pro-apoptotic stimuli such IL3-deprivation that induce LCN2 expression (PubMed:12130540). In neural stem cells the expression is induced by retinoic acid (PubMed:23090999). {ECO:0000269|PubMed:12130540, ECO:0000269|PubMed:21768648, ECO:0000269|PubMed:23090999}.
Developmental stage：Expressed in sensory neurons during embryonic development of the olfactory epithelium and vomeronasal organ. From, at least, 11.5 dpc through adulthood, expressed in the olfactory system. At 14.5 dpc, highly expressed in the olfactory epithelia, vomeronasal organ, the Grueneberg ganglion, the septal organ and the olfactory bulb (PubMed:23090999). At 14.5 dpc, expressed within germinal regions in the ventricular zone of the brain, the rhombic lip and the nascent external granule layer (EGL). At 16.5 dpc expression at the EGL is more intense and extensive. From P1 to P15, expressed in cerebellar granule neuron progenitor cells (CGNPs) of the EGL (PubMed:22095825). {ECO:0000269|PubMed:12213205, ECO:0000269|PubMed:22095825, ECO:0000269|PubMed:23090999}.
Protein families：BZIP family