GFRA4_MOUSE Q9JJT2
We list detailed information on various proteins on this webpage, which EnkiLife references when developing protein-related products. The protein data is sourced from UniProt, and since UniProt updates its information periodically, the data on our webpage may not always be up-to-date or may contain inaccuracies. If you notice any errors while browsing, we warmly welcome your feedback. Additionally, if you have any suggestions regarding any aspect of our website, please feel free to share them with us. As a token of our appreciation, we will offer a free product or a discount voucher for purchases to scientists who provide feedback. Please contact us at Email: order@enkilife.com; to share your feedback and get your rewards.
UniProt:Q9JJT2
Recommended name：GDNF family receptor alpha-4
EC number：
Alternative names：(GDNF receptor alpha-4) (GDNFR-alpha-4) (GFR-alpha-4) (Persephin receptor)
Cleaved into：
GeneID：14588
Gene names (primary )：Gfra4
Gene names (synonym )：
Gene names (ORF )：
Length：260
Mass：27990
Sequence：MAHCMESALLLLLLLGSASFTDGNRCVDAAEACTADERCQQLRSEYVARCLGRAAPGGRPGPGGCVRSRCRRALRRFFARGPPALTHALLFCGCEGSACAERRRQTFAPACAFSGPGLVPPSCLEPLERCERSRLCRPRLLAFQASCAPAPGSRDRCPEEGGPRCLRVYAGLIGTVVTPNYLDNVSARVAPWCGCAASGNRREECEAFRKLFTRNPCLDGAIQAFDSLQPSVLQDQTAGCCFPRVSWLYALTALALQALL
Tissue specificity：Expressed in many tissues including adrenal medulla, brain neurons, with highest levels in the cerebral cortex and hippocampus. Moderate levels found in the gut circular muscle and myenteric ganglia as well as in other peripheral ganglia, including the sensory dorsal root and trigeminal as well as superior cervical and sympathetic chain ganglia. Isoform a1, isoform a2, isoform b1 and isoform b2 are exclusively found in the thyroid, parthyroid and pituitary glands.
Induction：
Developmental stage：Expressed in several tissues at different embryonic and postnatal stages such as the condensing mesenchyme of developing bones and developing nervous system. Expressed in the developing pituitary gland from 16 dpc and in developing thyroid C-cells from 14 dpc. In the ventral spinal cord, levels decline before birth. In the parathyroid, levels first detected in 3- to 6-week-old mice with high expression. In the adrenal medulla, expressed only in newborn, postnatal (P08) and adult mice. Isoform a1 and isoform b1 are prefentially expressed in 3-week-old thyroid, isoform a2 and isoform b2 in newborn and 6-week-old thyroid glands as well as in postnatal adrenal and pituitary glands.
Protein families：GDNFR family