LYAR_MOUSE Q08288
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UniProt:Q08288
Recommended name：Cell growth-regulating nucleolar protein
EC number：
Alternative names：(Ly1 antibody-reactive protein) (Protein expressed in male leptotene and zygotene spermatocytes 264) (MLZ-264)
Cleaved into：
GeneID：17089
Gene names (primary )：Lyar
Gene names (synonym )：
Gene names (ORF )：
Length：388
Mass：43736
Sequence：MVFFTCNACGESVKKIQVEKHVSNCRNCECLSCIDCGKDFWGDDYKSHVKCISEGQKYGGKGYEAKTHKGDAKQQAWIQKINELIKKPNVSPKVRELLQQISAFDNVPRKKAKFQNWMKNSLKVHSDSVLEQVWDIFSEASSSEQDQQQPPSHTAKPHAEMPITKVPSAKTNGTTEEQTEAKKNKRERKEERQKNRKKEKKELKLENHQENLRGQKPKKRKKNQEAGHEAAGEEAAEASGPPEKKKAQGGQASEEGADRNGGPGEDAAEGQTKTAAGKRKRPKHSGAESGYKKKKMKLPEQPEEGEAKDHEAPSKGKFNWKGTIKAVLKQAPDNEISVKKLKKKVIAQYHAVMNDHHTSEEELLAIFNRKISRNPTFKVLKDRVKLLK
Tissue specificity：Predominantly expressed in testis, in germ cells, and at a moderate level in spleen, liver and lung (at protein level) (PubMed:19489080, PubMed:23212345, PubMed:24990247). Very high levels in spermatogonia, spermatocytes and round spermatids, but not in testicular sperm and mature sperm (at protein level) (PubMed:20339383, PubMed:23212345, PubMed:24990247). Expressed in ovary (PubMed:20339383). Expressed in the retina, including in photoreceptor outer segments (at protein level) (PubMed:25735755). Expressed in undifferentiated embryonic stem cells (PubMed:19489080, PubMed:23212345). {ECO:0000269|PubMed:19489080, ECO:0000269|PubMed:20339383, ECO:0000269|PubMed:23212345, ECO:0000269|PubMed:24990247, ECO:0000269|PubMed:25735755}.
Induction：
Developmental stage：Expressed in testis and ovary at 15.5 dpc (PubMed:20339383). May be differentially expressed during spermatogenesis. Detected first at P12, the early stage of spermatogenesis. Levels considerably increase at P16, corresponding to the development of pachytene spermatocytes (PubMed:23212345). {ECO:0000269|PubMed:20339383, ECO:0000269|PubMed:23212345}.
Protein families：