SIX3_MOUSE Q62233
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UniProt:Q62233
Recommended name：Homeobox protein SIX3
EC number：
Alternative names：(Sine oculis homeobox homolog 3)
Cleaved into：
GeneID：20473
Gene names (primary )：Six3
Gene names (synonym )：
Gene names (ORF )：
Length：333
Mass：35593
Sequence：MVFRSPLDLYSSHFLLPNFADSHHCSLLLASSGGGSGASGGGGGAGGGGGGNRAGGGGAGGAGGGSGGGGSRAPPEELSMFQLPTLNFSPEQVASVCETLEETGDIERLGRFLWSLPVAPGACEAINKHESILRARAVVAFHTGNFRDLYHILENHKFTKESHGKLQAMWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAKNRLQHQAIGPSGMRSLAEPGCPTHGSAESPSTAASPTTSVSSLTERADTGTSILSVTSSDSECDV
Tissue specificity：Expressed in ependymal cells during the formation of the lateral wall. {ECO:0000269|PubMed:22071110}.
Induction：Represses its own transcription in a TLE4-dependent manner. Induces in lens by PAX6 in a dosage-dependent manner. Activated by SOX2 during forebrain development. Inhibited by MTA1 in mammary glands. {ECO:0000269|PubMed:12050133, ECO:0000269|PubMed:12072567, ECO:0000269|PubMed:23792023}.
Developmental stage：Expressed in the developing retina (at protein level). First expressed at 6.5 dpc of embryo development around the anterior border. At 8.5 dpc, expression is found over the anterior neural plate. At 9.5 dpc, in the diencephalic part of the ventral forebrain, optic vesicles, olfactory placodes and Rathke pouch. In later stages, present in hypothalamus, eyes and pituitary. Expression at around 7.5 dpc to 8 dpc is high in the anterior neural ectoderm. Weaker expression is detected in the prechordal plate. At the 5 somite stage (8.0 dpc), expression is maintained in the anterior neural ectoderm. Around the 8 somite stage (8.0 dpc), expression is already restricted to the ventral forebrain and eye field. At the 12 somite stage (8.5 dpc), expression is maintained in the ventral forebrain (PubMed:18694563). At 9.5 dpc strongly expressed throughout the prospective nasal ectoderm. At 10.5 dpc remains expressed throughout the nasal ectoderm (PubMed:16024294). At 7.5 dpc expression is found in the developing anterior neuroectoderm. At 9.0 dpc expression is found in the region of the presumptive lens ectoderm and developing optic vesicle. At 9.5 dpc expression is found in the lens placode, optic vesicles, and ventral forebrain (PubMed:11458394). {ECO:0000269|PubMed:11458394, ECO:0000269|PubMed:16024294, ECO:0000269|PubMed:18694563}.
Protein families：SIX/Sine oculis homeobox family