HEY2_MOUSE Q9QUS4
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UniProt:Q9QUS4
Recommended name：Hairy/enhancer-of-split related with YRPW motif protein 2
EC number：
Alternative names：(HES-related repressor protein 2) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HRT-2) (mHRT2) (Protein gridlock homolog)
Cleaved into：
GeneID：15214
Gene names (primary )：Hey2
Gene names (synonym )：Chf1 Herp Herp1 Hesr2 Hrt2
Gene names (ORF )：
Length：339
Mass：35873
Sequence：MKRPCEETTSESDLDETIDVGSENNYPGHATSSVMRSNSPTTTSQIMARKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGSAKLEKAEILQMTVDHLKMLQATGGKGYFDAHALATDFMSIGFRECLTEVARYLSSVEGLDPSDPLRVRLVSHLSTCASQREAAVMTSSMAHHHHPLHPHHWAAAFHHLPTALLQPNGLHTSESTPCRLSTSSEVPSAHGSALLTATFAHADSALRMPSGGTVAPCVPPLSTSLLSLSATVHAAAAAATAAAHSFPLSFAGAFPMLPSNAAAAAAVAAATAISPPLSVSAASSPQQTSTGTNNKPYQPWGTEVGAF
Tissue specificity：Highly expressed in the aorta, lower expression detected in the heart, brain, kidney, lung, muscle, ovary and testis. {ECO:0000269|PubMed:10588864, ECO:0000269|PubMed:10692439, ECO:0000269|PubMed:10860664, ECO:0000269|PubMed:12947105}.
Induction：By activation of the Notch signaling pathway. {ECO:0000269|PubMed:10964718, ECO:0000269|PubMed:11095750, ECO:0000269|PubMed:11741889}.
Developmental stage：Expressed in the developing somites and the ventricles of the heart. Expressed in the otic vesicles between 8.5 dpc and 10.5 dpc. Expressed in the myocardium of the ventricles at 9.5 dpc and in the atrioventricular cushions from 9.5 to 12.5 dpc. At 10.5 dpc, strongly expressed in the spinal nerves, the cranial ganglia and the telencephalon. At 11.5 dpc, expressed in the craniofacial region of the distal part of the maxillary arch, along the rostral mandibular arch and surrounding the lateral nasal processes. Expressed in the midbrain-hindbrain boundary and the posterior edge of the hand- and foot-paddle. Expressed in the mediodorsal region of the telencephalon and the ventricular zone of the ventral spinal cord at 12 dpc, then in the ventral region of the telencephalon and the cortical plate at 15 dpc. Expression in the heart is limited to the compact myocardial layer at 17.5 dpc. Also expressed in the developing retina up to P5, at which point expression decreases. {ECO:0000269|PubMed:10415358, ECO:0000269|PubMed:10588864, ECO:0000269|PubMed:10692439, ECO:0000269|PubMed:10860664, ECO:0000269|PubMed:11160397, ECO:0000269|PubMed:12947105, ECO:0000269|PubMed:16199874, ECO:0000269|PubMed:17259303, ECO:0000269|PubMed:17303760, ECO:0000269|PubMed:17332425}.
Protein families：HEY family