OTOG_MOUSE O55225
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UniProt:O55225
Recommended name：Otogelin
EC number：
Alternative names：
Cleaved into：
GeneID：18419
Gene names (primary )：Otog
Gene names (synonym )：Otgn
Gene names (ORF )：
Length：2911
Mass：313620
Sequence：MGARMPRRCLLLLSCFCLLRVESTAEVQHQASALTWKISAELQQEPAPEPSHTYQEMSLAVEDVTTVMEGQEAEALAASAMSSWERRLHRAKCAPSYLFSCFNGGECVHPALCDCRRFNATGPRCQLVYNVGPERDSICRTWGQHHVETFDGLYYYFSGKGSYTLVGHHEPEGQSFSIQVHNDPQCGSAHYTCPRSVSLFLSGEREICLAKEVTHGGVRVQLPQVVGGVQLQQLAGYVIARHPSAFTLAWDGISAIYIKMSPEFLGWTHGLCGNNNADPQDDLVTSYGKVTDDVGEFVHSWQEQVPNSPPGPVTTSLPRPPCLQQSPASMQGVYERCEVLLRPPFDTCHAYVSPLPFAASCTSDLCQSGGDEATWCRALMEYARACAQAGRPLQGWRTQLSQCTVHCKEKAFIYNECIACCPASCQSRASCVDSEITCVDGCYCPNGLIFEDGGCMSPAECPCEFHGTLHPPGSVVTEDCNACTCTAGKWVCSSSVCPAECSVTGDIHFTTFDGRRYTFPATCQYILAKSRSSGTFTVTLQNAPCGLNQDGACVQSVSVILHQDPRRQVTLTQAGDVLLFDQYKITPPYSDDAFEIRRLSSVFLRVRTNVGVRILYDREGLRLYLQVDQRWVEDTVGLCGTFNGNTQDDFLSPVGVPESTPQLFGNSWKTLSACVPLVPGSLLDPCDVHLQAASYALQSCSVLTGELFAPCSAYLSPIPYFEQCRRDACRCGQPCLCATLAHYARLCRRHGLPVDFRAHLPACALSCEATKEYSPCVTLCAPTCQDLASPDVCGANGGGNFSREECVEGCTCPPDTFLDTQADLCVPRNQCSCHFQGVDYPPGDSDIPSLGHCHCKDGVMSCDSRAPAAACPAGQVFVNCSELHPDPELSRERTCEQQLLNLSVPARGPCLSGCACPQGLLRHGDACFPPEECPCTWKGKEYFPGDQVVSSCHTCVCQRGSFQCTLHPCASTCTAYGDRHYRTFDGLPYDFVGACKVHLVKSTSELSFSVMVEDVNCYGSGVICRKSISINVGSSLIIFDDDSGDPSPESFLDEKQAVHIWRAGFFTLVHFPREHITLLWDQRTTVHVQAGPQWQGQLVGLCGNFDLKTINEMRTPENLELTNPQEFGSSWAAVECPDTPDPRDTCVLNPLREPFARKECGILLSEVFETCHPVVDVTWFYSNCLTDTCGCSRGGDCECFCASVAAYAHQCCQHGVVIDWRTPRICPYDCDFFNKALGKGPYQLSSVAAGGTLVATKAVDSDIALVRAEDLAPGDISSFLLTAALYKAKAHDPDVVSLEAADRPNFFLHTTANGSIGLAKWQRDEAFHQHASFSLHRGTWQAGLVALESLAKPGSFLHSSGLELALRAYEHTEVFRGGALFRLLDAKPLGAAYPTCEWRYDACASPCFQTCRDPRATSCQDVPRVEGCVPVCPTPKVLDEVTQRCVYLEDCVEPAPRGPTETLGNETLVPGQVPPTTSAEQQLPQGLPGASAYSPAPVPVAPPTSAPNPPMAATEGQAPSPGSTQPTLQTPLGLTTSNFPAGHTEATAREEGAASLLTTSHPPGFSSSLPSSLQMPTSGIVSGATETTKVTITFTGSPNTTVASRSPPIPRFPLMTKAVTVPSHDSFPVKTTPLQPSWLWSLSSRPMTSLGATSWPPTSPGSHLSTAVTKVANKTMTSLSVLAQSTSSSSQPLAAVTTAHRAPASPLVTKGLEVVSATEKGEAGHSQLTELPVSPPPSPAPIDLPHPAQHTTTAPGPSALSPGILAAGSPSTGAHRPGATALASLEPTRPPHLLSGLPLDTSLPLAKVGTSAPVATPGSKGYIPTPPPQHQATTLATAMTVSPLTQSLSLTVPLMSAVEEQAHSPSPKPPQGTGMAPDQMLGATLPSFGASSVIAGVPPTVSAAPRKSTTQRAAILSKKVSPPTLISDSVQGGFTELTPIVSHTVTPLATEAEGPRAGTVPLVPTTYSLSRVSARTASREGPLVLLPQLAEAYGTPAGLQPQEDLVRQATTEQSGRSAPAKSIAEESMEAEVNTSATCVPIAEQDCVRHICLEGQLIRVNQTQHCPQGAVRPRCGVLGLAVRVGGDRCCPQWECACRCSIFPDLSFVTFDGSHAALFKEAIYVLSQSPDETISVHVLDCKSANLGHLNWPPFCLVILNVTHLAHHVSIDRFNRKVTVDSQVVWPPMSRYGFRIEDTGHMYIVRTPSHIQIQWLHSSGLMILEASKVSKTQGHGLCGICDGDAANDLTLKDGSVLGEAEDPAPFLDSWQVPSSLTSEGQTRFRPDSCATADCSPCLRMVSNRTFSACHSFVSPESFCELWIRDTKYVQQPCVALTVYVAMCHKFHVCIEWRGSDYCPFLCSSDSTYQACVAACEPPDTCQDGILGPLDPEQCQVLGEGCVCTEGTILHRRHSALCIPEDKCACTDSTGVPRALGETWNSSLSGCCQQQCQAPDTIIPVDLDCPGPRPESCPRFGEVILLQPTEDPCCLGSVCVCNQTLCEGLAPTCRPGHSLITHFQEDSCCPSYSCECDPGLCEAEQVPTCREDQILIEGRLGDSCCTSYFCGCGECSDPMPECQEGEALTVHRNTTELCCPLYQCVCENFRCPQVQCGMGTSLVEVWSPDRCCPYKSCECDCDTIPVPRCHLWEKSQLDEEFMHSVENVCGCAKYECVKAPVCLSRELGVMQPGQTVVELSADGVCHTSRCTDVLDPLTNFYQINITSVLCDMHCEANQEYDHPRDLAACCGSCRNVSCLFTFPNGTTSLFLPGASWIADCARHHCGSTPLGAVLVRSPISCPPFNETECAKVGGSVVPSLEGCCRACKEDGRSCKKVTIRMTIRKNDCRSNTPVNLVSCDGRCPSASIYNHNINTYARFCKCCREVGLQRRSVQLFCATNATWVPYTVQEPTDCACQWS
Tissue specificity：Expressed specifically in neuroepithelial supporting cells of the inner ear. Expressed in the cochlea between postnatal day P0 and P6 in pseudostratified cells of the greater epithelial ridge, in supporting cells of the neuroepithelium comprising Deiter's, Hensen's, pillar and Claudius cells, in epithelial cells of the Reissner's membrane, in a small set of cells comprising the spiral prominence. Expressed in the cochlea at P15 in interdental cells located underneath the limbal part of the tectorial membrane. Expressed in the vestibular apparatus at P0 in supporting cells of the saccular, utricular maculae and cristae ampullares, in the epithelial cells of the roof of the saccule but not in the roof of the utricle and cristae ampullares (at protein level). Expressed in the cochlea and vestibular organ of the inner ear. {ECO:0000269|PubMed:11506947, ECO:0000269|PubMed:9405633}.
Induction：
Developmental stage：Expressed in the epithelial cells of the otic vesicle at 10 dpc. Expressed in non-sensory cells of the developing vestibule, in the transitory epithelium of the saccule, utricle and cristae ampullares, in epithelial cells of the roof of the saccule, but not the roof of the utricle nor the cristae ampullares at 13 dpc. Expressed in supporting cells of the vestibular maculae at 13 dpc onward birth. Expressed in non-sensory cells of the emerging cochlear duct at 12 dpc. Expressed in the pluristratified sensory epithelium as well as in the epithelium of the roof at 14 dpc. Expressed in the developing sensory epithelium (the spiral limbus, the greater epithelial ridge and the lesser epithelial ridge) of the cochlear duct, the interdental cells of the spiral limbus and in the columnar cells that form the greater epithelial ridge at 16 and 17 dpc. Expressed in the non-sensory pillar, Deiter's and Hensen's cells of the organ of Corti and Claudius cells at 19 dpc onward birth (at protein level). {ECO:0000269|PubMed:10655058, ECO:0000269|PubMed:11506947}.
Protein families：Otogelin family