PO4F1_MOUSE P17208
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UniProt:P17208
Recommended name：POU domain, class 4, transcription factor 1
EC number：
Alternative names：(Brain-specific homeobox/POU domain protein 3A) (Brain-3A) (Brn-3A) (Brn-3.0)
Cleaved into：
GeneID：18996
Gene names (primary )：Pou4f1
Gene names (synonym )：Brn-3 Brn3 Brn3a
Gene names (ORF )：
Length：421
Mass：42767
Sequence：MMSMNSKQPHFAMHPTLPEHKYPSLHSSSEAIRRACLPTPPLQSNLFASLDETLLARAEALAAVDIAVSQGKSHPFKPDATYHTMNSVPCTSTSTVPLAHHHHHHHHHQALEPGDLLDHISSPSLALMAGAGGAGAAGGGGGAHDGPGGGGGPGGGGGPGGGGPGGGGGGGGPGGGGGGPGGGLLGGSAHPHPHMHGLGHLSHPAAAAAMNMPSGLPHPGLVAAAAHHGAAAAAAAAAAGQVAAASAAAAVVGAAGLASICDSDTDPRELEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPILQAWLEEAEGAQREKMNKPELFNGGEKKRKRTSIAAPEKRSLEAYFAVQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKFSATY
Tissue specificity：Expressed in mature osteoclasts (at protein level) (PubMed:17668438). Brain, peripheral sensory nervous system and retina (PubMed:8162704). In the adult nervous system, predominates in the medial habenula, superficial gray of the superior colliculus, red nucleus, mesencephalic nucleus of the trigeminal ganglion, nucleus ambiguus, inferior olivary nucleus, and peripheral sensory ganglia (PubMed:8290353). {ECO:0000269|PubMed:17668438, ECO:0000269|PubMed:8162704, ECO:0000269|PubMed:8290353}.
Induction：Up-regulated by the osteoclast differentiation factor TNFSF11 (PubMed:17668438). {ECO:0000269|PubMed:17668438}.
Developmental stage：Expressed in the spinal cord from 11 dpc to the adult stage (PubMed:8290353). As early as 10.5 dpc to 15.5 dpc, strongly expressed in all dorsal root ganglion neurons (PubMed:22326227). In retinal ganglion cells, expression starts at 15.5 dpc and exhibits a slow decrease with moderate levels detectable at P8 (PubMed:8637595). {ECO:0000269|PubMed:22326227, ECO:0000269|PubMed:8290353, ECO:0000269|PubMed:8637595}.
Protein families：POU transcription factor family, Class-4 subfamily