CIC_MOUSE Q924A2
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UniProt:Q924A2
Recommended name：Protein capicua homolog
EC number：
Alternative names：
Cleaved into：
GeneID：71722
Gene names (primary )：Cic
Gene names (synonym )：Kiaa0306
Gene names (ORF )：
Length：2510
Mass：258130
Sequence：MKPMKKACPGLAGSASGSKSPPATRAKALRRRGAGEGDKPEEEEEAQPQEQAGPEEAEEGEEEEAERDPGAEGTHPELQPNDPTPGLTEDPKGDGEAGRWEPSLSRKTATFKSRAPKKKYVEEHGTGNVGVVGAPEERERTPEDASALGVPPRPPTSTRSSSTDTASEHSADLEDEPPEACGPGPWPSTGTSEGYDLRQLRSQRVLARRGDGLFLPAVVRQVRRSQDLGVQFPGDRALTFYEGVPGGGVDVVLDVTPPPGALMVGTAVCTCVEPGVAAYREGVVVEVATKPAAYKVRLSPGPSSHAGPPGTLPQAQQTLHREPEEAVWVTRSSLRLLRPPWEPGALLRKHPAGPEEEQAEPGPALPPCPSSVEPKQPEDAEVSNISFGSNLGTRCEEGEEKHPPSLGTPVLLPLPPPQLLSPPPKSPAFGGPGRPSEQPSPCQEGSQGGSRSSSVASLEKGAAPAARARTPLTAAQQKYKKGDVVCTPNGIRKKFNGKQWRRLCSRDGCMKESQRRGYCSRHLSMRTKEMEGLADSGPGGTGRPAGVAAREGSTEFDWGDETSRDSEASSVAARGDSRPRLVAPADLSRFEFDECEAAVMLVSLGSSRSGTPSFSPVSTQSPFSPAPSPSPSPLFGFRPANFSPINASPVIQRTAVRSRHLSASTPKAGVLTPPDLGPHPPPPAPRERHSSGILPTFQTNLTFTVPISPGRRKTELLPHPGTLGASGAGGGGAAPDFPKSDSLDSGVDSVSHTPTPSTPAGFRAVSPAVPFSRSRQPSPLLLLPPPAGLTSDPGPSVRRVPAVQRDSPVIVRNPDVPLPSKFPGEVGTAGEARAGGPGRSCRETPVPPGVASGKPGLPPPLPAPVPITVPPAAPTAVAQPMPTLGLASSPFQPVAFHPSPAALLPVLVPSSYPSHPAPKKEVIMGRPGTVWTNVEPRSVAVFPWHSLVPFLAPSQPDPSVQPSEAQQPASHPVASNQSKEPAESAAVAHEQPPGGTGGADPGRPPGAVCPESPGPGPPLTLGGVDPGKSLPPTTEEEAPGPPGEPRLDSETESDHDDAFLSIMSPEIQLPLPPGKRRTQSLSALPKERDSSSEKDGRSPNKREKDHIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWCNKDRKKSSSEAKPASLGLAGGHKETRERSMSETGTAAAPGVSSELLSVAAQTLLSSDTKVPGSGPCGAERLHAVGAPGSARPRAFSHSGVHSLDGGEVDSQALQELTQMVSGPASYSGPKPSPQYGAPGSFAAPGEGGTLATSGRPPLLPSRASRSQRAASEDMTSDEERMVICEEEGDDDVIADDSFGTTDIDLKCKERVTDSESGDSSGEDPEGNKGFGRKVFSPVIRSSFTHCRPTLDPEPPGPPDPPAAFSKGYGPTPSSSSSPASTSVSVSTSFSLGSGTFKTQESGQGSTAVPLRPPPPGAGGPATPSKATRFPPTDSATFRRKRPESVGSLEAPGPSVIAAPPSGGGNLLQTLVLPPSKEDREGTRVPSAPAPPLAYGAPAAPLCRPAATMVTNVVRPVSSTPVPIASKPFPTSGRAEASSNDIAGARTEMGTGSRVPGGSPMGVSLVYSDKKSAAAATSPAPHLVAGPLLGTVGKAPATVTNLLVGTPGYGAPASPAVQFIAQGAPGSATPAGSGASTGSGPNGPVPLGILQPGALGKAGGITQVQYILPTLPQQLQVAPAPAPAPGTKAAAPSGPAPTTSIRFTLPPGTSTNGKVLAATAPTAGIPILQSVPSAPPPKAQSVSPVQATPSGGSAQLLPGKVLVPLAAPSMSVRGGGAGQPLPLVSSPFSVPVQNGAQQPSKIIQLTPVPVSTPSGLVPPLSPATMPGPTSQPQKVLLPSSTRITYVQSAGGHTLPLGTSSACSQTGTVTSYGPTSSVALGFTSLGPSGPAFVQPLLSGQAPLLAPGQVGVSPVPSPQLPPACTASGGPVITAFYPGSPAPTSAPLGPPSQAPPSLVYTVATSTTPPAATILPKGPPASATATPAPTSPFPSATGSMTYSLVAPKAQRPSPKAPQKVKAAIASIPVGSFESGTTGRPGSTPRQSSDSGVAREPAAPESELEGQPTPPAPPPPTETWPPTARSSPPPPLPAEERPGTKGPETASKFPSSSSDWRVPGLGLESRGEPPTPPSPAPATGPSGSSSGSSEGSSGRAAGDTPERKEVTSSGKKMKVRPPPLKKTFDSVDKVLSEVDFEERFAELPEFRPEEVLPSPTLQSLATSPRAILGSYRKKRKNSTDLDSAPEDPTSPKRKMRRRSSCSSEPNTPKSAKCEGDIFTFDRTGTETEDVLGELEYEKVPYSSLRRTLDQRRALVMQLFQDHGFFPSAQATAAFQARYADIFPSKVCLQLKIREVRQKIMQAATPTEQPPGAEAPLPGPPPTGMAATPVPTPSPAGGPDPTSPGSDSGTAQVAPPLPPPPEPGPGQPGWEGAPQPSPPPSGPSTAATGR
Tissue specificity：Expressed in the cortex and hypothalamus (at protein level). Isoform 1: Present in cerebellum (at protein level) (PubMed:17190598). Isoform 2: Present in cerebellum (at protein level) (PubMed:17190598). {ECO:0000269|PubMed:17190598, ECO:0000269|PubMed:28288114}.
Induction：
Developmental stage：Expressed postnatally in the hippocampus, neocortex, olfactory bulb and cerebellum. Expressed in the hippocampus from P0 to P15. Expressed in the posterior region of the neocortex at P4, the anterior region at P9, and is then lost by P15. Expressed in the cerebellum from P0, specifically within the external granule layer (EGL) which contains granule cell precursors. By P7 expression is distributed throughout the EGL and is reduced in the inner granule cell layer (IGL) where granule cells finally differentiate. Expression in the IGL continues to diminish up to P15, when granule cell neurogenesis is complete. {ECO:0000269|PubMed:12393275, ECO:0000269|PubMed:15981098}.
Protein families：