H2AB1_MOUSE   Q9CQ70


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UniProt:Q9CQ70

Recommended name:Histone H2A-Bbd type 1

EC number:

Alternative names:(H2A Barr body-deficient) (H2A.Bbd) (Histone H2A-like 2) (H2A.L.2) (H2AL2) (Histone H2Alike 2) (Testis-specific expressed gene 1 protein) (TSEG-1)

Cleaved into:

GeneID:68231

Gene names  (primary ):H2ab1

Gene names  (synonym ):H2afb1 H2al2a

Gene names  (ORF ):

Length:111

Mass:12843

Sequence:MARKRQRRRRRKVTRSQRAELQFPVSRVDRFLREGNYSRRLSSSAPVFLAGVLEYLTSNILELAGEVAHTTGRKRIAPEHVCRVVQNNEQLHQLFKQGGTSVFEPPEPDDN

Tissue specificity:Highly expressed in adult testis, mainly in spermatocytes (PubMed:20008104, PubMed:20188161, PubMed:17261847). {ECO:0000269|PubMed:17261847, ECO:0000269|PubMed:20008104, ECO:0000269|PubMed:20188161}.

Induction:

Developmental stage:Expressed since postnatal day (P) 21, peaks at P30, and gradually decreases in the testis of aging mouse (PubMed:20008104, PubMed:20188161). Coexpressed with transition proteins during late spermiogenesis (PubMed:28366643). Strongly enriched in step 12-16 spermatids and accumulate during late spermiogenesis, in condensing spermatids (PubMed:17261847). Remains present in mature spermatozoa isolated from epididymis (PubMed:17261847). Rapidly disappears from the paternal pericentric heterochromatin regions after sperm-egg fusion (PubMed:18703863). {ECO:0000269|PubMed:17261847, ECO:0000269|PubMed:18703863, ECO:0000269|PubMed:20008104, ECO:0000269|PubMed:20188161, ECO:0000269|PubMed:28366643}.

Protein families:Histone H2A family


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