CEAM2_MOUSE Q925P2
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UniProt:Q925P2
Recommended name：Carcinoembryonic antigen-related cell adhesion molecule 2
EC number：
Alternative names：(CEA-related cell adhesion molecule 2) (Biliary glycoprotein 2) (BGP-2)
Cleaved into：
GeneID：26367
Gene names (primary )：Ceacam2
Gene names (synonym )：Bgp2
Gene names (ORF )：
Length：520
Mass：57202
Sequence：MELASAHLHKGQVPWFGLLLTASLLASWSPPTTAQVTVMAFPLHAAEGNNVILVVYNMMKGVSAFSWHKGSTTSTNAEIVRFVTGTNKTIKGPVHSGRETLYSNGSLLIQRVTMKDTGVYTIEMTDQNYRRRVLTGQFHVHTLLLKSNITSNNSNPVEGDDSVSLTCDSYTDPDNITYLWSRNGESLSEGDRLKLSEGNRTLTLLNVTRNDTGPYVCETRNPVSVNRSDPFSLNIIYGPDTPIISPSDIYLHPGSNLNLSCHAASNPPAQYFWLINEKPHASSQELFIPNITTNNSGTYTCFVNNSVTGLSRTTVKNITVLEPVTQPSLQVTNTTVKELDSVTLTCLSKDRQAHIHWIFNNDTLLITEKMTTSQAGLILKIDPIKREDAGEYQCEISNPVSVKRSNSIKLEVIFDSTYDISDVPIAVIITGAVAGVILIAGLAYRLCSRKSRWGSDQRDLTEHKPSASNHNLAPSDNSPNKVDDVAYTVLNFNSQQPNRPTSAPSSPRATETVYSEVKKK
Tissue specificity：Isoform 2 is detected in elongating spermatids within the seminiferous epithelium (at protein level). Expressed in kidney, colon, uterus, gut mononuclear cells, crypt epithelia of intestinal tissues, and to a lesser extent, in spleen. Expressed in brain including VMH, globus pallidus, ventral pallidum, striatum, olfactory bulb and hippocampus. Also detected in rectal carcinoma cell line CMT93. Isoform 2 and isoform 3 are expressed in testis. Isoform 2 is detected in seminiferous tubule, not detected in epididymal spermatozoa. Also not observed on spermatogonia, spermatocytes, round spermatids or somatic Sertoli cells. During stages I-VII of spermatogenesis, detected on the elongating spermatids. At spermiation (stage VIII) and subsequent stages IX-XII, levels are drastically reduced or absent in the seminiferous tubules. Sometimes weakly detected in the apical region of stage-VIII seminiferous epithelium. Isoform 2 level is very low in stomach, kidney, intestine, liver and spleen. {ECO:0000269|PubMed:10491101, ECO:0000269|PubMed:11284729, ECO:0000269|PubMed:20381490, ECO:0000269|PubMed:23070997, ECO:0000269|PubMed:8207827}.
Induction：Levels in brain increase at fasting and decrease at 4 and 7 hours of refeeding. {ECO:0000269|PubMed:20381490}.
Developmental stage：Expressed throughout embryonic development. Isoform 2 first appears faintly in the testis 3 weeks into postnatal development and its expression level increases after 5 weeks. {ECO:0000269|PubMed:11284729, ECO:0000269|PubMed:23070997}.
Protein families：Immunoglobulin superfamily, CEA family