SGPL1_MOUSE Q8R0X7
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UniProt:Q8R0X7
Recommended name：Sphingosine-1-phosphate lyase 1
EC number：EC 4.1.2.27
Alternative names：(S1PL) (SP-lyase 1) (SPL 1) (mSPL) (Sphingosine-1-phosphate aldolase)
Cleaved into：
GeneID：20397
Gene names (primary )：Sgpl1
Gene names (synonym )：Spl
Gene names (ORF )：
Length：568
Mass：63677
Sequence：MPGTDLLKLKDFEPYLEILESYSTKAKNYVNGYCTKYEPWQLIAWSVLCTLLIVWVYELIFQPESLWSRFKKKLFKLIRKMPFIGRKIEQQVSKAKKDLVKNMPFLKVDKDYVKTLPAQGMGTAEVLERLKEYSSMDGSWQEGKASGAVYNGEPKLTELLVQAYGEFTWSNPLHPDIFPGLRKLEAEIVRMTCSLFNGGPDSCGCVTSGGTESILMACKAYRDLALEKGIKTPEIVAPESAHAAFDKAAHYFGMKIVRVALKKNMEVDVQAMKRAISRNTAMLVCSTPQFPHGVMDPVPEVAKLAVRYKIPLHVDACLGGFLIVFMEKAGYPLEKPFDFRVKGVTSISADTHKYGYAPKGSSVVMYSNEKYRTYQFFVGADWQGGVYASPSIAGSRPGGIIAACWAALMHFGENGYVEATKQIIKTARFLKSELENIKNIFIFGDPQLSVIALGSNDFDIYRLSNMMSAKGWNFNYLQFPRSIHFCITLVHTRKRVAIQFLKDIRESVTQIMKNPKAKTTGMGAIYGMAQATIDRKLVAEISSVFLDCLYTTDPVTQGNQMNGSPKPR
Tissue specificity：Highest levels are found in liver, small intestine and thymus, followed by kidney, lung, heart, spleen and brain (at protein level). Also detected in stomach, testis and skeletal muscle (at protein level). {ECO:0000269|PubMed:15522238, ECO:0000269|PubMed:20097939, ECO:0000269|PubMed:28165339, ECO:0000269|PubMed:9464245}.
Induction：
Developmental stage：Expressed throughout mouse embryogenesis.A transient increase is observed from 5.5 dpc to 7.5 dpc. {ECO:0000269|PubMed:15522238}.
Protein families：Group II decarboxylase family, Sphingosine-1-phosphate lyase subfamily