DMTF1_MOUSE Q8CE22
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UniProt:Q8CE22
Recommended name：Cyclin-D-binding Myb-like transcription factor 1
EC number：
Alternative names：(Cyclin-D-interacting Myb-like protein 1) (mDmp1)
Cleaved into：
GeneID：23857
Gene names (primary )：Dmtf1
Gene names (synonym )：Dmp1
Gene names (ORF )：
Length：761
Mass：84644
Sequence：MSTVEEDSDTVTVETVNSVTFTQDTDGNLILHCPQNDPDEVDSEDSTEPPHKRLCLSSEDDQSIDDATPCISVVALPLSENDQSFEVTMTATTEVADDELSEGTVTQIQILQNDQLDEISPLGTEEVSAVSQAWFTTKEDKDSLTNKGHKWKQGMWSKEEIDILMNNIERYLKARGIKDATEIIFEMSKDERKDFYRTIAWGLNRPLFAVYRRVLRMYDDRNHVGKYTPEEIEKLKELRIKHGNDWATIGAALGRSASSVKDRCRLMKDTCNTGKWTEEEEKRLAEVVHELTSTEPGDIVTQGVSWAAVAERVGTRSEKQCRSKWLNYLNWKQSGGTEWTKEDEINLILRIAELDVADENDINWDLLAEGWSSVRSPQWLRSKWWTIKRQIANHKDVSFPVLIKGLKQLHENQKNNPVLLENKSGSGVPNSNCNSSVQHVQIRVARLEDNTAISPSPMAALQIPVQITHVSSTDSPAASVDSETITLNSGTLQTFEILPSFHLQPTGTPGTYLLQTSSSQGLPLTLTTNPTVTLAAAAPASPEQIIVHALSPEHLLNTSDNVTVQCHTPRVIIQTVATEDITSSLSQEELTVDSDLHSSDFPEPPDALEADTFPDEIPRPKMTIQPSFNNAHVSKFSDQNSTELMNSVMVRTEEEIADTDLKQEEPPSDLASAYVTEDLESPTIVHQVHQTIDDETILIVPSPHGFIQASDVIDTESVLPLTTLTDPIFQHHQEASNIIGSSLGSPVSEDSKDVEDLVNCH
Tissue specificity：Ubiquitously expressed (at mRNA level). Expressed in brain, intestine, kidney, lung, pancreas, skin, spleen and tongue (at protein level). Expressed at high levels in testis and thymus (at protein level). In all tissues examined, expression is predominant in non-proliferating and differentiated cell types. These include epithelial, interstitial and smooth muscle cells of the intestine, differentiated spermatids, sperm and interstitial cells of the testis, and lymphoid cells of the medullary compartment of the thymus. {ECO:0000269|PubMed:10898794, ECO:0000269|PubMed:16878159, ECO:0000269|PubMed:8887674}.
Induction：Expression is induced by activation of the Ras-Raf signaling pathway, and this may require JUN and JUNB. Expression can be repressed by E2F1, E2F2, E2F3 and E2F4. Expression is also repressed by non-classical inhibitors of NF-kappa-B signaling such as doxorubicin, daunorubicin and UVC, and by the NF-kappa-B p65 subunit (RELA). {ECO:0000269|PubMed:15601844, ECO:0000269|PubMed:16878159, ECO:0000269|PubMed:17546045}.
Developmental stage：Expressed throughout the cell cycle. Expression is highest in G0 and G1 phases and decreases during S and G2/M phases. {ECO:0000269|PubMed:16878159, ECO:0000269|PubMed:8887674}.
Protein families：DMTF1 family