KAT2A_MOUSE Q9JHD2
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UniProt:Q9JHD2
Recommended name：Histone acetyltransferase KAT2A
EC number：EC 2.3.1.48
Alternative names：(General control of amino acid synthesis protein 5-like 2) (Histone acetyltransferase GCN5) (MmGCN5) (Histone glutaryltransferase KAT2A) (Histone succinyltransferase KAT2A) (Lysine acetyltransferase 2A)
Cleaved into：
GeneID：14534
Gene names (primary )：Kat2a
Gene names (synonym )：Gcn5l2
Gene names (ORF )：
Length：830
Mass：93394
Sequence：MAEPSQAPNPVPAAQPRPLHSPAPAPTSTPAPSPASASTPAPTPAPAPAPAAAPAGSTGSGGAGVGSGGDPARPGLSQQQRASQRKAQVRGLPRAKKLEKLGVFSACKANETCKCNGWKNPKPPTAPRMDLQQPAANLSELCRSCEHPLADHVSHLENVSEDEINRLLGMVVDVENLFMSVHKEEDTDTKQVYFYLFKLLRKCILQMTRPVVEGSLGSPPFEKPNIEQGVLNFVQYKFSHLAPRERQTMFELSKMFLLCLNYWKLETPAQFRQRSQSEDVATYKVNYTRWLCYCHVPQSCDSLPRYETTHVFGRSLLRSIFTVTRRQLLEKFRVEKDKLVPEKRTLILTHFPKFLSMLEEEIYGANSPIWESGFTMPPSEGTQLVPRPATVSATVVPSFSPSMGGGSNSSLSLDSAGTEPMPAGEKRKLPENLTLEDAKRLRVMGDIPMELVNEVMLTITDPAAMLGPETSLLSANAARDETARLEERRGIIEFHVIGNSLTPKANRRVLLWLVGLQNVFSHQLPRMPKEYIARLVFDPKHKTLALIKDGRVIGGICFRMFPTQGFTEIVFCAVTSNEQVKGYGTHLMNHLKEYHIKHSILYFLTYADEYAIGYFKKQGFSKDIKVPKSRYLGYIKDYEGATLMECELNPRIPYTELSHIIKKQKEIIKKLIERKQAQIRKVYPGLSCFKEGVRQIPVESVPGIRETGWKPLGKEKGKELKDPDQLYTTLKNLLAQIKSHPSAWPFMEPVKKSEAPDYYEVIRFPIDLKTMTERLRSRYYVTRKLFVADLQRVIANCREYNPPDSEYCRCASALEKFFYFKLKEGGLIDK
Tissue specificity：In brain, highly expressed in the hippocampal CA1 region (at protein level) (PubMed:25024434). Also expressed in the hippocampal subregions CA3 and the dentate gyrus as well as in the cortex and prefrontal cortex (PubMed:25024434). Expressed at low level in the cerebellum (PubMed:25024434). {ECO:0000269|PubMed:25024434}.
Induction：
Developmental stage：Expressed uniformly throughout the embryo from 7.5 to 9.0 dpc, except in the distal allantois and developing heart. Gcn5l2 expression is down-regulated after 16.5 dpc, but is later up-regulated in specific adult tissues. {ECO:0000269|PubMed:11017084}.
Protein families：Acetyltransferase family, GCN5 subfamily