KCNC3_MOUSE Q63959
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UniProt:Q63959
Recommended name：Potassium voltage-gated channel subfamily C member 3
EC number：
Alternative names：(KSHIIID) (Voltage-gated potassium channel subunit Kv3.3)
Cleaved into：
GeneID：16504
Gene names (primary )：Kcnc3
Gene names (synonym )：
Gene names (ORF )：
Length：769
Mass：81946
Sequence：MLSSVCVWSFRGRQGTGKQQPQPVPTPQPPESSPPPLPPPQQQQCSQPGTAASPAGAPLSCGPGGRRAEPCPGLPAVAMGRHGGGGGDSGKIVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARFDYDPGTDEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELGFWGIDETDVEACCWMTYRQHRDAEEALDSFEAPDSSANANANAGGAHDAGLDDEAGAGGGGLDGAGGELKRLCFQDAGGGAGGPAGGAGGAGGTWWRRWQPRVWALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGFIHISNKTVTQASPIPGAPPENITNVEVETEPFLTYVEGVCVVWFTFEFLMRVTFCPDKVEFLKSSLNIIDCVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKNKHIPRPPQPGSPNYCKPDPPPPPPPHPHHGSGGISPPPPITPPSMGVNVAGAYPPGPHTHPGLLRGGAGGLGIMGLPPLPAPGEPCPLAQEEVIETNRADPRPNGDPAAAALAHEDCPAIDQPAMSPEDKSPITPGSRGRYSRDRACFLVTDYAPSPDGSIRKGYEKSRSLSSIVGLSGVSLRLAPLATPPGSPRATRRAPPTLPSIL
Tissue specificity：Detected on Purkinje cells in the dentate, interposed and medial nucleus in cerebellum (PubMed:15217387, PubMed:18448641). Detected in brainstem (PubMed:18539595). Detected at calyces of Held in the auditory brain stem (at protein level) (PubMed:26997484). Isoform KV3.3B is highly enriched in the brain, particularly in the cerebellum, where its expression is confined to Purkinje cells and deep cerebellar nuclei. Isoform KV3.3A is not expressed in cerebellum. {ECO:0000269|PubMed:15217387, ECO:0000269|PubMed:18448641, ECO:0000269|PubMed:18539595, ECO:0000269|PubMed:26997484, ECO:0000269|PubMed:8301351}.
Induction：
Developmental stage：Expression begins in cerebellar Purkinje cells between postnatal day 8 (P8) and P10 and continues through adulthood. {ECO:0000269|PubMed:8301351}.
Protein families：Potassium channel family, C (Shaw) (TC 1.A.1.2) subfamily, Kv3.3/KCNC3 sub-subfamily