K1C12_MOUSE Q64291
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UniProt:Q64291
Recommended name：Keratin, type I cytoskeletal 12
EC number：
Alternative names：(Cytokeratin-12) (CK-12) (Keratin-12) (K12)
Cleaved into：
GeneID：
Gene names (primary )：Krt12
Gene names (synonym )：Krt1-12 Krt1.12
Gene names (ORF )：
Length：487
Mass：52464
Sequence：MSLSVCTSALSRRSSSQNGAAGRPWGASASSVAGGYGGSASGFGVGCGGLFSAASMFGSSSGFSGGSAGCLPGLGSAYGGPLRGGAGGMGIGMGIAGSSGGGSLCIFSGNDGGLLSGSEKETMQNLNDRLASYLGKVRSLEEANAELENKIREWYETRRTRDAGSQSDYSKYYPLIEDLKNKIVSARVSNAQLLLQIDNARLAAEDFRMKYENELALRQTVEADINGLRRVLDELTLTRADLEAQLETLTEELAYMKKNHEEELQSFQAGGPGEVNVEMDAAPGVDLTKVLNEMRAQYEAMAEQNRKDAEAWFLEKSGELRKEISSNTEQLQSSKSEVTDLKRMVQNLEIELQSQLAMKSSLEGSLAETEGGYCCQLSQVQQLIGSLEEQLQQVRADAERQNADHQRLLGVKARLEMEIETYRRLLEGDSQGDGFDESSSLSVSKPQTPSVDSSKDPNKTRKIKTVVQEIVNGEVVSSQVQELEEEM
Tissue specificity：Expressed in the corneal epithelium (at protein level) (PubMed:7508359, PubMed:8977471, PubMed:26758872). Also expressed in the suprabasal limbal epithelium of the cornea (at protein level) (PubMed:7508359). {ECO:0000269|PubMed:26758872, ECO:0000269|PubMed:7508359, ECO:0000269|PubMed:8977471}.
Induction：Expression is retarded by epidermal growth factor (EGF). {ECO:0000269|PubMed:7508359}.
Developmental stage：Expression commences in corneal peridermal epithelium in the embryo at 15.5 dpc (PubMed:16431949). Between 15.5 dpc and postnatal day 4 (P4), expression is restricted to the suprabasal and/or superficial cells when the corneal epithelium begins to stratify (PubMed:7508359, PubMed:16431949). At P30 expression is sporadically detected in the basal corneal epithelium and the number of positive basal cells increases as the mice grow older (PubMed:16431949). {ECO:0000269|PubMed:16431949, ECO:0000269|PubMed:7508359}.
Protein families：Intermediate filament family