FFAR4_MOUSE Q7TMA4
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UniProt:Q7TMA4
Recommended name：Free fatty acid receptor 4
EC number：
Alternative names：(G-protein coupled receptor 120) (G-protein coupled receptor GT01) (Omega-3 fatty acid receptor 1)
Cleaved into：
GeneID：107221
Gene names (primary )：Ffar4
Gene names (synonym )：Gpr120 O3far1
Gene names (ORF )：
Length：361
Mass：40813
Sequence：MSPECAQTTGPGPSHTLDQVNRTHFPFFSDVKGDHRLVLSVVETTVLGLIFVVSLLGNVCALVLVARRRRRGATASLVLNLFCADLLFTSAIPLVLVVRWTEAWLLGPVVCHLLFYVMTMSGSVTILTLAAVSLERMVCIVRLRRGLSGPGRRTQAALLAFIWGYSALAALPLCILFRVVPQRLPGGDQEIPICTLDWPNRIGEISWDVFFVTLNFLVPGLVIVISYSKILQITKASRKRLTLSLAYSESHQIRVSQQDYRLFRTLFLLMVSFFIMWSPIIITILLILIQNFRQDLVIWPSLFFWVVAFTFANSALNPILYNMSLFRNEWRKIFCCFFFPEKGAIFTDTSVRRNDLSVISS
Tissue specificity：Highly expressed in brown and white adipose tissue (PubMed:27853148, PubMed:17250804, PubMed:24222669). Expressed in perivascular ciliated preadipocytes (at protein level) (PubMed:31761534). Expressed in the taste buds of the circumvallate and fungiform papillae, mainly in type II cells (at protein level) (PubMed:19071193, PubMed:20573884). Abundant expression is detected in the gastrointestinal tract (PubMed:15619630, PubMed:27853148, PubMed:17250804, PubMed:24222669). Highly expressed in lung and pituitary gland (PubMed:15619630, PubMed:17250804). Expressed in enteroendocrine K cells of the upper small intestine (PubMed:25535828). Expressed in alpha and delta cells of pancreatic islets (PubMed:24742677, PubMed:24663807). Expressed in proinflammatory CD11C-positive macrophages (PubMed:20813258). Also expressed in spleen (PubMed:17250804). {ECO:0000269|PubMed:15619630, ECO:0000269|PubMed:17250804, ECO:0000269|PubMed:19071193, ECO:0000269|PubMed:20573884, ECO:0000269|PubMed:20813258, ECO:0000269|PubMed:24222669, ECO:0000269|PubMed:24663807, ECO:0000269|PubMed:24742677, ECO:0000269|PubMed:25535828, ECO:0000269|PubMed:27853148, ECO:0000269|PubMed:31761534}.
Induction：Up-regulated in response to high-fat diet in adipose tissue macrophages and in hepatic Kupffer cells (PubMed:17250804, PubMed:20813258). Up-regulated in response to either short- or long-term cold exposure in brown adipose tissue and inguinal white adipose tissue (PubMed:27853148). Up-regulated by ADRB3 agonist (PubMed:29343498). {ECO:0000269|PubMed:17250804, ECO:0000269|PubMed:20813258, ECO:0000269|PubMed:27853148, ECO:0000269|PubMed:29343498}.
Developmental stage：Expression detected in differentiated mature adipocytes, with levels increasing during late stage adipocyte differentiation (PubMed:17250804, PubMed:29343498). Low expression is detected in preadipocytes, mainly localized in primary cilium (PubMed:31761534). Expression level in bone marrow mesenchymal stem cells is gradually increased during differentiation toward osteoblasts (PubMed:26365922). {ECO:0000269|PubMed:17250804, ECO:0000269|PubMed:26365922, ECO:0000269|PubMed:29343498, ECO:0000269|PubMed:31761534}.
Protein families：G-protein coupled receptor 1 family