K1C17_MOUSE Q9QWL7
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UniProt:Q9QWL7
Recommended name：Keratin, type I cytoskeletal 17
EC number：
Alternative names：(Cytokeratin-17) (CK-17) (Keratin-17) (K17)
Cleaved into：
GeneID：16667
Gene names (primary )：Krt17
Gene names (synonym )：Krt1-17
Gene names (ORF )：
Length：433
Mass：48162
Sequence：MTTTIRQFTSSSSIKGSSGLGGGSSRTSCRLSGSLGAGSCRLGSASGLGSALGSNSYSSCYSFGTGSGYGGNFGGVDGLLAGGEKATMQNLNDRLASYLDKVRALEEANTELEVKIRDWYQKQAPGPARDYSAYYHTIEDLKNKILVATVDNASILLQIDNARLAADDFRTKFETEQALRMSVEADINGLRRVLDELTLARADLEMQIENLKEELAYLKKNHEEEMNALRGQVGGEINVEMDAAPGVDLSRILSEMRDQYEKMAEKNRKDAEDWFFSKTEELNREVATNSELVQSGKSEISELRRTMQALEIELQSQLSMKASLEGSLAETENRYCVQLSQIQGLIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAHLTQYKPKEPVTTRQVRTIVEEVQDGKVISSREQVHQTTR
Tissue specificity：Expressed strongly in outer root sheath and medulla region of hair follicle and in the early differentiating epithelial cells (trichocytes) within the hair bulb region. Weak expression in the matrix cells of hair bulb. Also present in the sweat gland within the skin, vibrissae follicle, salivary gland, tooth and thymus. {ECO:0000269|PubMed:10844551, ECO:0000269|PubMed:14714564, ECO:0000269|PubMed:2433272}.
Induction：Induced in damaged or stressed epidermis and by interferon-gamma. Up-regulated by LEF1. {ECO:0000269|PubMed:2433272, ECO:0000269|PubMed:9786956}.
Developmental stage：Expression first occurs in a subset of epithelial cells within the single-layered, undifferentiated ectoderm of embryonic day 10.5 mouse fetuses. In the ensuing 48 hours, K17-expressing cells give rise to placodes, the precursors of ectoderm-derived appendages (hair, glands, and tooth), and to periderm. {ECO:0000269|PubMed:9786956}.
Protein families：Intermediate filament family