NDEL1_MOUSE Q9ERR1
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UniProt:Q9ERR1
Recommended name：Nuclear distribution protein nudE-like 1
EC number：
Alternative names：(Protein mNudE-like) (Protein Nudel) (mNudE-L)
Cleaved into：
GeneID：83431
Gene names (primary )：Ndel1
Gene names (synonym )：Nudel
Gene names (ORF )：
Length：345
Mass：38366
Sequence：MDGEDIPDFSSLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQELAVRERQQEVTRKSAPSSPTLDCEKMDSAVQASLSLPATPVGKGTENSFPSPKAIPNGFGTSPLTPSARISALNIVGDLLRKVGALESKLAACRNFAKDQASRKSYVPGSVNCGVMNSNGPECPRSGRATFFHKGAVNGFDPAPPPPGLGSSRPSSAPGMLPLSV
Tissue specificity：Expressed in brain, liver, lung and testis (at protein level). Expressed in brain, epididymis, eye, heart, kidney, large intestine, liver, ovary, pancreas, prostate, skeletal muscle, smooth muscle, spleen, submaxillary gland, testis, thymus and thyroid. Within the brain expression is pronounced in the cortex, hippocampus, olfactory bulb, striatum, thalamic and hypothalamic structures and in the molecular layer of the cerebellum. Largely excluded from cortical progenitor cells which express NDE1. {ECO:0000269|PubMed:11163259, ECO:0000269|PubMed:11163260, ECO:0000269|PubMed:11231056, ECO:0000269|PubMed:15147871}.
Induction：
Developmental stage：Expression in the brain is detectable from 7 dpc, rises at 15 dpc and 17 dpc and peaks at P5. Enriched in the developing cortex, particularly in neuroblasts of the ventricular zone and postmitotic migrating cortical plate neurons. Interaction with DISC1 in the brain is developmentally regulated, peaking at 17 dpc and decreasing at P16 so as to be undetectable in the adult brain. Expressed in the testis from P12, when zygotene spermatocytes first appear, and expression subsequently rises at P27. {ECO:0000269|PubMed:11163260, ECO:0000269|PubMed:11231056, ECO:0000269|PubMed:15147871, ECO:0000269|PubMed:15473966, ECO:0000269|PubMed:15473967}.
Protein families：NudE family